Accelerometric measurement of involuntary movements during pallidal deep brain stimulation of patients with generalized dystonia

• Published in: Brain research bulletin 2004-12, Vol.64 (4), p.363-369
• Main Authors: Legros, A., Diakonova, N., Cif, L., Hemm, S., Vayssière, N., Coubes, P., Beuter, A.
• Format: Article
• Language: English
• Subjects: Accelerometry; Adolescent; Adult; Child; Deep Brain Stimulation - methods; Dyskinesias - etiology; Dyskinesias - therapy; Dystonic Disorders - complications; Dystonic Disorders - therapy; Female; Generalized dystonia; Glasgow Outcome Scale; Globus Pallidus - physiopathology; Globus Pallidus - radiation effects; Humans; Male; Neurologic Examination; Posture - physiology; Quantitative evaluation; Rest - physiology; Spectrum Analysis; Statistics, Nonparametric; Treatment Outcome
• ISSN: 0361-9230; 1873-2747
• DOI: 10.1016/j.brainresbull.2004.09.002

Accelerometric activity during rest and posture was quantified in the upper dominant limb of 14 patients with primary or secondary dystonia and five healthy control subjects. Data were recorded before and after bilateral implantation of the stimulating electrodes in the Globus Pallidus internus. Clinical evaluation was based on the Burke–Marsden–Fahn's Dystonia Rating Scale (BMFDRS). For the patient group, I t, the integral (i.e. area) of the acceleration power spectrum over the total frequency range (0.6–16 Hz) decreased as the clinical state of the patients improved following deep brain stimulation ( p < 0.01) during rest and posture. Ten days after surgery, there were no I t differences between control subjects and patients ( p > 0.05). A significant correlation was found between the global BMFDRS scores and I t for rest ( p < 0.01) but not for posture. No significant correlation was found between I t and a partial BMFDRS score for the right arm for rest or posture. The integral I t provides a valid indicator of the motor activity generated by the arm of the patient but further analyses are needed to monitor patients’ progress not only during their hospitalization but also after they are released from the hospital, and to understand why this measure does not correlate with partial BMFDRS scores.