Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report

This is a report of a 7-year-old girl suffering from widespread calvarial defects after severe head injury with multifragment calvarial fractures, decompressive craniectomy for refractory intracranial hypertension and replantation of cryopreserved skull fragments. Chronic infection resulted in an un...

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Bibliographic Details
Published in:Journal of cranio-maxillo-facial surgery 2004-12, Vol.32 (6), p.370-373
Main Authors: Lendeckel, Stefan, Jödicke, Andreas, Christophis, Petros, Heidinger, Kathrin, Wolff, Jan, Fraser, John K., Hedrick, Marc H., Berthold, Lars, Howaldt, Hans-Peter
Format: Article
Language:English
Subjects:
Absorbable Implants
Adipocytes - transplantation
Autologous bone graft
Biological and medical sciences
Bone Regeneration - physiology
Bone Transplantation - methods
Child
Dentistry
Female
Fibrin glue
Fibrin Tissue Adhesive - therapeutic use
Follow-Up Studies
Fracture Fixation - instrumentation
Fractures, Closed - surgery
Humans
Medical sciences
Membranes, Artificial
Otorhinolaryngology. Stomatology
Skull defects
Skull Fractures - surgery
Stem Cell Transplantation
Stem cells
Tissue Adhesives - therapeutic use
Tissue and Organ Harvesting
Transplantation, Autologous
Wound Healing - physiology
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Summary:This is a report of a 7-year-old girl suffering from widespread calvarial defects after severe head injury with multifragment calvarial fractures, decompressive craniectomy for refractory intracranial hypertension and replantation of cryopreserved skull fragments. Chronic infection resulted in an unstable skull with marked bony defects. Two years after the initial injury the calvarial defects were repaired. Due to the limited amount of autologous cancellous bone available from the iliac crest, autologous adipose derived stem cells were processed simultaneously and applied to the calvarial defects in a single operative procedure. The stem cells were kept in place using autologous fibrin glue. Mechanical fixation was achieved by two large, resorbable macroporous sheets acting as a soft tissue barrier at the same time. The postoperative course was uneventful and CT-scans showed new bone formation and near complete calvarial continuity three months after the reconstruction.
ISSN:1010-5182
1878-4119
DOI:10.1016/j.jcms.2004.06.002