Clinicopathological features of incidental hepatocellular carcinoma in liver transplantation

The incidence of detecting hepatocellular carcinoma (HCC) in a removed recipient liver after a liver transplant is not rare. The clinical features are expected to be different from the preoperatively diagnosed HCC. The aim of this study was to evaluate the clinicopathological features of incidental...

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Bibliographic Details
Published in:Transplantation proceedings 2004-10, Vol.36 (8), p.2293-2294
Main Authors: Choi, S.H., Lee, H.H., Lee, D.S., Choi, J.H., Heo, J.S., Lee, K.W., Joh, J.W., Kim, S.J., Yoo, B.C., Lee, J.H., Choi, M.S., Choe, Y.H., Lee, S.K.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Carcinoma, Hepatocellular - pathology
Fundamental and applied biological sciences. Psychology
Fundamental immunology
Gastroenterology. Liver. Pancreas. Abdomen
Humans
Liver Neoplasms - pathology
Liver Transplantation - mortality
Liver Transplantation - pathology
Liver. Biliary tract. Portal circulation. Exocrine pancreas
Medical sciences
Retrospective Studies
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Survival Analysis
Tissue, organ and graft immunology
Tomography, X-Ray Computed
Treatment Outcome
Tumors
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Summary:The incidence of detecting hepatocellular carcinoma (HCC) in a removed recipient liver after a liver transplant is not rare. The clinical features are expected to be different from the preoperatively diagnosed HCC. The aim of this study was to evaluate the clinicopathological features of incidental HCC. This study retrospectively analyzed five cases of incidental HCC among 51 liver transplant cases of HCC operated from September 1996 to February 2002. The proportion of an incidental HCC was 9.8%. The mean age was 46.2 years with a higher prevalence in may (80%, four cases). The alpha-fetoprotein level was normal or mildly elevated. HBsAg was positive in all cases. Imaging studies revealed regenerative or dysplastic nodules, or no specific lesion. The pathological findings demonstrated a mean size of 1.16 cm, multiplicity in three cases (60%), no microvascular invasion, and Edmonson grade I (60%) and II (40%). There was no recurrence of the HCC. However, two patients died due to an intracranial hemorrhage and a graft failure, respectively. In conclusion, incidentally found HCC showed less invasive pathological features and a better prognosis.
ISSN:0041-1345
1873-2623
DOI:10.1016/j.transproceed.2004.08.076