A new molecularly imprinted polymer for the selective extraction of naproxen from urine samples by solid-phase extraction

A non-covalent molecularly imprinted polymer (MIP) was synthesised using naproxen (a non-steroidal, anti-inflammatory drug (NSAID)) as a template molecule. The MIP was chromatographically evaluated to confirm the imprinting effect, and was then applied as a selective sorbent in solid-phase extractio...

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Bibliographic Details
Published in:Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Analytical technologies in the biomedical and life sciences, 2004-12, Vol.813 (1), p.137-143
Main Authors: Caro, Ester, Marcé, Rosa M., Cormack, Peter A.G., Sherrington, David C., Borrull, Francesc
Format: Article
Language:English
Subjects:
Analysis
Analytical, structural and metabolic biochemistry
Anti-Inflammatory Agents, Non-Steroidal - urine
Biological and medical sciences
Chromatography, Liquid
Fundamental and applied biological sciences. Psychology
General pharmacology
Human urine samples
Medical sciences
Molecularly imprinted polymer
Naproxen
Naproxen - urine
Pharmacology. Drug treatments
Polymers - chemistry
Solid-phase extraction
Spectrophotometry, Ultraviolet
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Summary:A non-covalent molecularly imprinted polymer (MIP) was synthesised using naproxen (a non-steroidal, anti-inflammatory drug (NSAID)) as a template molecule. The MIP was chromatographically evaluated to confirm the imprinting effect, and was then applied as a selective sorbent in solid-phase extraction (SPE) to selectively extract naproxen. After this study, the MIP was used to extract naproxen from urine samples; it was demonstrated that by applying a selective washing step with acetonitrile (ACN) the compounds in the sample that were structurally related to naproxen could be eliminated.
ISSN:1570-0232
1873-376X
DOI:10.1016/j.jchromb.2004.09.019