Atrial Arrhythmias in Long-QT Syndrome under Daily Life Conditions: A Nested Case Control Study

Background: The long‐QT syndromes (LQTS) are inherited electrical cardiomyopathies characterized by prolonged ventricular repolarization and ventricular arrhythmias. Several genetic reports have associated defects in LQTS‐causing genes with atrial fibrillation (AF). We therefore studied whether atri...

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Published in:Journal of cardiovascular electrophysiology 2009-04, Vol.20 (4), p.401-407
Main Authors: ZELLERHOFF, STEPHAN, PISTULLI, RUDIN, MÖNNIG, GEROLD, HINTERSEER, MARTIN, BECKMANN, BRITT-MARIA, KÖBE, JULIA, STEINBECK, GERHARD, KÄÄB, STEFAN, HAVERKAMP, WILHELM, FABRITZ, LARISSA, GRADAUS, RAINER, BREITHARDT, GÜNTER, SCHULZE-BAHR, ERIC, BÖCKER, DIRK, KIRCHHOF, PAULUS
Format: Article
Language:English
Subjects:
action potential
Activities of Daily Living
Adolescent
Adrenergic beta-Antagonists - therapeutic use
Adult
Aged
Aged, 80 and over
atrial fibrillation
Atrial Fibrillation - genetics
Atrial Fibrillation - prevention & control
Case-Control Studies
Child
clinical study
Defibrillators, Implantable
Electrocardiography
Female
Germany
Humans
Long QT Syndrome - complications
Long QT Syndrome - drug therapy
Long QT Syndrome - genetics
Long QT Syndrome - therapy
long-QT syndrome
Male
Middle Aged
Pacemaker, Artificial
Time Factors
torsades de pointes
Treatment Outcome
Young Adult
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Summary:Background: The long‐QT syndromes (LQTS) are inherited electrical cardiomyopathies characterized by prolonged ventricular repolarization and ventricular arrhythmias. Several genetic reports have associated defects in LQTS‐causing genes with atrial fibrillation (AF). We therefore studied whether atrial arrhythmias occur in patients with LQTS under daily‐life conditions. Methods: We systematically assessed atrial arrhythmias in LQTS patients and matched controls using implanted defibrillators or pacemakers as monitors of atrial rhythm in a nested case‐control study. Twenty‐one LQTS patients (3 male; 39 ± 18 years old; 18 on β blocker, ICD therapy duration 6.3 ± 2.7 years; 4 LQT1, 6 LQT2, 2 LQT3) were matched to 21 control subjects (13 male; 50 ± 19 years old; 3 on β blocker; pacemaker therapy duration 8.5 ± 5.5 years; 19 higher‐degree AV block, 2 others). LQTS patients were identified by a systematic search of the LQTS patient databases in Münster and Munich. Results: One‐third (7 of 21) of the LQTS patients developed self‐terminating atrial arrhythmias (atrial cycle lengths
ISSN:1045-3873
1540-8167
DOI:10.1111/j.1540-8167.2008.01339.x