The effect of simvastatin therapy on hemorheological profile in coronary heart desease (CHD) patients

This study was designed to examine changes of hemorheological parameters in patients with CHD and hypercholesterolaemia (wide range of plasma total cholesterol level from 5.6 to 9.8 mmol.l-1) subjected to lipid lowering therapy with statins (simvastatin, 10.0-20.0 mg/day, dosage was dependent on an...

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Bibliographic Details
Published in:Clinical hemorheology and microcirculation 2004, Vol.31 (4), p.251-256
Main Authors: Muravyov, Alexei V, Yakusevich, Vladimir V, Surovaya, Larisa, Petrochenko, Aleksandr
Format: Article
Language:English
Subjects:
Blood Viscosity - drug effects
Coronary Disease - blood
Coronary Disease - drug therapy
Erythrocyte Aggregation - drug effects
Erythrocyte Deformability - drug effects
Female
Hematocrit
Hemorheology - drug effects
Humans
Hypercholesterolemia - blood
Hypercholesterolemia - drug therapy
Lipids - blood
Middle Aged
Simvastatin - administration & dosage
Simvastatin - therapeutic use
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Summary:This study was designed to examine changes of hemorheological parameters in patients with CHD and hypercholesterolaemia (wide range of plasma total cholesterol level from 5.6 to 9.8 mmol.l-1) subjected to lipid lowering therapy with statins (simvastatin, 10.0-20.0 mg/day, dosage was dependent on an initial level of total cholesterol). Twenty female subjects were enrolled in this research program. Both prior to and following drug treatment for eight weeks, hemorheological measurements included plasma viscosity, high and low shear whole blood viscosity, hematocrit, RBC aggregation and rigidity. Treatment with simvastatin significantly (p
ISSN:1386-0291