Health-related quality of life in Italian patients with systemic lupus erythematosus. I. Relationship between physical and mental dimension and impact of age

Objective. To examine health-related quality of life (HRQOL) in Italian patients with systemic lupus erythematosus (SLE) and compare it with that of healthy people, and to investigate relationships among different dimensions and subscales of a generic health status measure. Methods. The Medical Outc...

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Bibliographic Details
Published in:Rheumatology (Oxford, England) England), 2004-12, Vol.43 (12), p.1574-1579
Main Authors: Rinaldi, S., Doria, A., Salaffi, F., Ermani, M., Iaccarino, L., Ghirardello, A., Zampieri, S., Sarzi-Puttini, P., Gambari, P. F., Perini, G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Biological and medical sciences
Female
Health Status Indicators
Health-related quality of life
Humans
Lupus Erythematosus, Systemic - psychology
Lupus Erythematosus, Systemic - rehabilitation
Male
Medical sciences
Mental Health
Middle Aged
Physical health
Quality of Life
Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis
SF-36
Surveys and Questionnaires
Systemic lupus erythematosus
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Summary:Objective. To examine health-related quality of life (HRQOL) in Italian patients with systemic lupus erythematosus (SLE) and compare it with that of healthy people, and to investigate relationships among different dimensions and subscales of a generic health status measure. Methods. The Medical Outcomes Study Short Form-36 (SF-36) was applied in a cohort of 126 consecutive SLE patients and 96 healthy controls. At the time of HRQOL testing, all patients underwent clinical and laboratory evaluation. Results. Both physical (PCS) and mental (MCS) component summary scores of the SF-36 were reduced in patients compared with controls. In SLE great variability in all the subscales was observed. Significant correlations between PCS and MCS and between many different subscales were observed in patients but not in controls. The PCS was higher than MCS more frequently in controls than in SLE patients (81 vs 48.4%, P
ISSN:1462-0324
1462-0332
DOI:10.1093/rheumatology/keh397