Eotaxin-1 (CCL11) up-regulation in tears during seasonal allergic conjunctivitis

To compare in-season eotaxin-1 levels in tears of patients suffering from seasonal allergic conjunctivitis (SAC) with (1) tears of normal subjects and (2) tears of SAC patients out of season. Tears of 11 SAC patients and six control volunteers were collected during the pollen season. Tears of five S...

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Bibliographic Details
Published in:Graefe's archive for clinical and experimental ophthalmology 2004-11, Vol.242 (11), p.966-970
Main Authors: Eperon, Simone, Sauty, Alain, Lanz, René, Leimgruber, Annette, Lurati, Floriana, Guex-Crosier, Yan
Format: Article
Language:English
Subjects:
Adult
Chemokine CCL11
Chemokines, CC - metabolism
Chemotactic Factors, Eosinophil - metabolism
Conjunctivitis, Allergic - metabolism
Enzyme-Linked Immunosorbent Assay
Female
Humans
Male
Ophthalmology
Prospective Studies
Seasons
Tears - metabolism
Up-Regulation
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Summary:To compare in-season eotaxin-1 levels in tears of patients suffering from seasonal allergic conjunctivitis (SAC) with (1) tears of normal subjects and (2) tears of SAC patients out of season. Tears of 11 SAC patients and six control volunteers were collected during the pollen season. Tears of five SAC patients showing a strong sensitivity to grass pollen (skin-prick tests and specific serum IgE) were collected both in season and out of season. ELISA measured eotaxin-1 level. Eotaxin-1 concentration in tears of SAC patients [2,100+/-503 (SEM) pg/ml] and normal subjects (1,193+/-176 pg/ml) were significantly different (P=0.0049). Regarding allergic patients, the clinical score (sum of five allergic criteria) was significantly different in season and out of season (P=0.0043) as was also the case with eotaxin-1 concentration (P=0.024). The eotaxin-1 concentration in tears of patients showing hay fever could confirm a diagnosis of seasonal ocular allergy.
ISSN:0721-832X
1435-702X
DOI:10.1007/s00417-004-0943-6