Combined Measurements of Cardiac Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Patients With Heart Failure

• Published in: Circulation Journal 2004, Vol.68(12), pp.1160-1164
• Main Authors: Taniguchi, Ryoji, Sato, Yukihito, Yamada, Tasuku, Ooba, Muneo, Higuchi, Hirokazu, Matsumori, Akira, Kimura, Takeshi, Kita, Toru
• Format: Article
• Language: English
• Subjects: Aged; Cardiac Output, Low - blood; Cardiac Output, Low - complications; Cardiac Output, Low - metabolism; Cardiac Output, Low - mortality; Chronic Disease; Death, Sudden, Cardiac; Female; Follow-Up Studies; Heart Diseases - etiology; Heart Diseases - mortality; Heart failure; Humans; Male; Middle Aged; Myocardium - metabolism; Natriuretic Peptide, Brain; Nerve Tissue Proteins - blood; Nerve Tissue Proteins - metabolism; Patient Readmission - statistics & numerical data; Peptide Fragments - blood; Peptide Fragments - metabolism; Pro-brain natriuretic peptide; Prognosis; Troponin; Troponin T - blood; Troponin T - metabolism
• ISSN: 1346-9843; 1347-4820
• DOI: 10.1253/circj.68.1160

Background To examine the prognostic contribution of combined cardiac troponin T (cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with heart failure (CHF) in the absence of acute coronary syndrome. Methods and Results Between July 2001 and March 2002, 71 consecutive patients (mean age = 68.4±1.4 years, 37 men), hospitalised for heart failure, were studied during hospitalisation and follow up until December 2002. Serum cTnT and NT-proBNP were measured on admission. Actuarial rates of adverse cardiac events, including sudden or CHF death, or rehospitalisation for CHF during follow up were compared with patients grouped according to initial serum cTnT and/or NT-proBNP concentrations. The adverse cardiac event-free rate among the 20 patients with cTnT ≥0.01 ng/ml was significantly lower than the 51 patients with cTnT