Combined Measurements of Cardiac Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Patients With Heart Failure

Background To examine the prognostic contribution of combined cardiac troponin T (cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with heart failure (CHF) in the absence of acute coronary syndrome. Methods and Results Between July 2001 and March 2002, 71 consecutive patien...

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Published in:Circulation Journal 2004, Vol.68(12), pp.1160-1164
Main Authors: Taniguchi, Ryoji, Sato, Yukihito, Yamada, Tasuku, Ooba, Muneo, Higuchi, Hirokazu, Matsumori, Akira, Kimura, Takeshi, Kita, Toru
Format: Article
Language:English
Subjects:
Aged
Cardiac Output, Low - blood
Cardiac Output, Low - complications
Cardiac Output, Low - metabolism
Cardiac Output, Low - mortality
Chronic Disease
Death, Sudden, Cardiac
Female
Follow-Up Studies
Heart Diseases - etiology
Heart Diseases - mortality
Heart failure
Humans
Male
Middle Aged
Myocardium - metabolism
Natriuretic Peptide, Brain
Nerve Tissue Proteins - blood
Nerve Tissue Proteins - metabolism
Patient Readmission - statistics & numerical data
Peptide Fragments - blood
Peptide Fragments - metabolism
Pro-brain natriuretic peptide
Prognosis
Troponin
Troponin T - blood
Troponin T - metabolism
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cited_by cdi_FETCH-LOGICAL-c481t-38f79985f95ec75dcbd28706201d287fd1fe1cc345ec740e7971a9a510df00103
cites cdi_FETCH-LOGICAL-c481t-38f79985f95ec75dcbd28706201d287fd1fe1cc345ec740e7971a9a510df00103
container_end_page 1164
container_issue 12
container_start_page 1160
container_title Circulation Journal
container_volume 68
creator Taniguchi, Ryoji
Sato, Yukihito
Yamada, Tasuku
Ooba, Muneo
Higuchi, Hirokazu
Matsumori, Akira
Kimura, Takeshi
Kita, Toru
description Background To examine the prognostic contribution of combined cardiac troponin T (cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with heart failure (CHF) in the absence of acute coronary syndrome. Methods and Results Between July 2001 and March 2002, 71 consecutive patients (mean age = 68.4±1.4 years, 37 men), hospitalised for heart failure, were studied during hospitalisation and follow up until December 2002. Serum cTnT and NT-proBNP were measured on admission. Actuarial rates of adverse cardiac events, including sudden or CHF death, or rehospitalisation for CHF during follow up were compared with patients grouped according to initial serum cTnT and/or NT-proBNP concentrations. The adverse cardiac event-free rate among the 20 patients with cTnT ≥0.01 ng/ml was significantly lower than the 51 patients with cTnT
doi_str_mv 10.1253/circj.68.1160
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Methods and Results Between July 2001 and March 2002, 71 consecutive patients (mean age = 68.4±1.4 years, 37 men), hospitalised for heart failure, were studied during hospitalisation and follow up until December 2002. Serum cTnT and NT-proBNP were measured on admission. Actuarial rates of adverse cardiac events, including sudden or CHF death, or rehospitalisation for CHF during follow up were compared with patients grouped according to initial serum cTnT and/or NT-proBNP concentrations. The adverse cardiac event-free rate among the 20 patients with cTnT ≥0.01 ng/ml was significantly lower than the 51 patients with cTnT &lt;0.01 ng/ml (P&lt;0.05). Similarly, the adverse cardiac event-free rate among the 36 patients with NT-proBNP ≥1,357 pg/ml (median) was significantly lower than the 35 patients with NT-proBNP &lt;1,357 pg/ml (P&lt;0.01). The 16 patients with high concentrations of both cTnT and NT-proBNP had a lower adverse cardiac event-free rate than the 31 patients with low cTnT and low NT-proBNP upon commencement of the study (P&lt;0.005). Conclusion Measurements of serum cTnT and NT-proBNP were reliable prognostic markers of adverse cardiac event in patients with CHF. (Circ J 2004; 68: 1160 - 1164)</description><identifier>ISSN: 1346-9843</identifier><identifier>EISSN: 1347-4820</identifier><identifier>DOI: 10.1253/circj.68.1160</identifier><identifier>PMID: 15564700</identifier><language>eng</language><publisher>Japan: The Japanese Circulation Society</publisher><subject>Aged ; Cardiac Output, Low - blood ; Cardiac Output, Low - complications ; Cardiac Output, Low - metabolism ; Cardiac Output, Low - mortality ; Chronic Disease ; Death, Sudden, Cardiac ; Female ; Follow-Up Studies ; Heart Diseases - etiology ; Heart Diseases - mortality ; Heart failure ; Humans ; Male ; Middle Aged ; Myocardium - metabolism ; Natriuretic Peptide, Brain ; Nerve Tissue Proteins - blood ; Nerve Tissue Proteins - metabolism ; Patient Readmission - statistics &amp; numerical data ; Peptide Fragments - blood ; Peptide Fragments - metabolism ; Pro-brain natriuretic peptide ; Prognosis ; Troponin ; Troponin T - blood ; Troponin T - metabolism</subject><ispartof>Circulation Journal, 2004, Vol.68(12), pp.1160-1164</ispartof><rights>2004 THE JAPANESE CIRCULATION SOCIETY</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-38f79985f95ec75dcbd28706201d287fd1fe1cc345ec740e7971a9a510df00103</citedby><cites>FETCH-LOGICAL-c481t-38f79985f95ec75dcbd28706201d287fd1fe1cc345ec740e7971a9a510df00103</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/15564700$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Taniguchi, Ryoji</creatorcontrib><creatorcontrib>Sato, Yukihito</creatorcontrib><creatorcontrib>Yamada, Tasuku</creatorcontrib><creatorcontrib>Ooba, Muneo</creatorcontrib><creatorcontrib>Higuchi, Hirokazu</creatorcontrib><creatorcontrib>Matsumori, Akira</creatorcontrib><creatorcontrib>Kimura, Takeshi</creatorcontrib><creatorcontrib>Kita, Toru</creatorcontrib><title>Combined Measurements of Cardiac Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Patients With Heart Failure</title><title>Circulation Journal</title><addtitle>Circ J</addtitle><description>Background To examine the prognostic contribution of combined cardiac troponin T (cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with heart failure (CHF) in the absence of acute coronary syndrome. Methods and Results Between July 2001 and March 2002, 71 consecutive patients (mean age = 68.4±1.4 years, 37 men), hospitalised for heart failure, were studied during hospitalisation and follow up until December 2002. Serum cTnT and NT-proBNP were measured on admission. Actuarial rates of adverse cardiac events, including sudden or CHF death, or rehospitalisation for CHF during follow up were compared with patients grouped according to initial serum cTnT and/or NT-proBNP concentrations. The adverse cardiac event-free rate among the 20 patients with cTnT ≥0.01 ng/ml was significantly lower than the 51 patients with cTnT &lt;0.01 ng/ml (P&lt;0.05). Similarly, the adverse cardiac event-free rate among the 36 patients with NT-proBNP ≥1,357 pg/ml (median) was significantly lower than the 35 patients with NT-proBNP &lt;1,357 pg/ml (P&lt;0.01). The 16 patients with high concentrations of both cTnT and NT-proBNP had a lower adverse cardiac event-free rate than the 31 patients with low cTnT and low NT-proBNP upon commencement of the study (P&lt;0.005). Conclusion Measurements of serum cTnT and NT-proBNP were reliable prognostic markers of adverse cardiac event in patients with CHF. (Circ J 2004; 68: 1160 - 1164)</description><subject>Aged</subject><subject>Cardiac Output, Low - blood</subject><subject>Cardiac Output, Low - complications</subject><subject>Cardiac Output, Low - metabolism</subject><subject>Cardiac Output, Low - mortality</subject><subject>Chronic Disease</subject><subject>Death, Sudden, Cardiac</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart Diseases - etiology</subject><subject>Heart Diseases - mortality</subject><subject>Heart failure</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Myocardium - metabolism</subject><subject>Natriuretic Peptide, Brain</subject><subject>Nerve Tissue Proteins - blood</subject><subject>Nerve Tissue Proteins - metabolism</subject><subject>Patient Readmission - statistics &amp; numerical data</subject><subject>Peptide Fragments - blood</subject><subject>Peptide Fragments - metabolism</subject><subject>Pro-brain natriuretic peptide</subject><subject>Prognosis</subject><subject>Troponin</subject><subject>Troponin T - blood</subject><subject>Troponin T - metabolism</subject><issn>1346-9843</issn><issn>1347-4820</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2004</creationdate><recordtype>article</recordtype><recordid>eNpNkLtuGzEQRYnAhq04LtMarNytPLPvLRM5jgzIjgoFKYkROWtR2IdCUjDy99mVhCjNcMB75hRXiM8IU4yz5EFbp7fTvJwi5vBBTDBJiygtY7g47HlUlWlyLT56vwWIK8iqK3GNWZanBcBEvM_6dm07NvKFye8dt9wFL_tazsgZS1quXL_rO9vJlaTOyNdoxa61HTVy6froq6MheqXg7HAcrJZL3gVrWA7fSwr2oPtlw0bOmVyQT2SbgfwkLmtqPN-e3hvx8-nbajaPFj--P8--LCKdlhiipKyLqiqzuspYF5nRaxOXBeQx4LjUBmtGrZN0jFPgoiqQKsoQTA2AkNyI-6N35_rfe_ZBtdZrbhrquN97lReImEIygNER1K733nGtds625P4oBDU2rQ5Nq7xUY9MDf3cS79ctmzN9qnYAHo_A1gd643_AUILVDf-ni09z9J7jDTnFXfIXVfGS7Q</recordid><startdate>20041201</startdate><enddate>20041201</enddate><creator>Taniguchi, Ryoji</creator><creator>Sato, Yukihito</creator><creator>Yamada, Tasuku</creator><creator>Ooba, Muneo</creator><creator>Higuchi, Hirokazu</creator><creator>Matsumori, Akira</creator><creator>Kimura, Takeshi</creator><creator>Kita, Toru</creator><general>The Japanese Circulation Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20041201</creationdate><title>Combined Measurements of Cardiac Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Patients With Heart Failure</title><author>Taniguchi, Ryoji ; Sato, Yukihito ; Yamada, Tasuku ; Ooba, Muneo ; Higuchi, Hirokazu ; Matsumori, Akira ; Kimura, Takeshi ; Kita, Toru</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-38f79985f95ec75dcbd28706201d287fd1fe1cc345ec740e7971a9a510df00103</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2004</creationdate><topic>Aged</topic><topic>Cardiac Output, Low - blood</topic><topic>Cardiac Output, Low - complications</topic><topic>Cardiac Output, Low - metabolism</topic><topic>Cardiac Output, Low - mortality</topic><topic>Chronic Disease</topic><topic>Death, Sudden, Cardiac</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart Diseases - etiology</topic><topic>Heart Diseases - mortality</topic><topic>Heart failure</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Myocardium - metabolism</topic><topic>Natriuretic Peptide, Brain</topic><topic>Nerve Tissue Proteins - blood</topic><topic>Nerve Tissue Proteins - metabolism</topic><topic>Patient Readmission - statistics &amp; numerical data</topic><topic>Peptide Fragments - blood</topic><topic>Peptide Fragments - metabolism</topic><topic>Pro-brain natriuretic peptide</topic><topic>Prognosis</topic><topic>Troponin</topic><topic>Troponin T - blood</topic><topic>Troponin T - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Taniguchi, Ryoji</creatorcontrib><creatorcontrib>Sato, Yukihito</creatorcontrib><creatorcontrib>Yamada, Tasuku</creatorcontrib><creatorcontrib>Ooba, Muneo</creatorcontrib><creatorcontrib>Higuchi, Hirokazu</creatorcontrib><creatorcontrib>Matsumori, Akira</creatorcontrib><creatorcontrib>Kimura, Takeshi</creatorcontrib><creatorcontrib>Kita, Toru</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Circulation Journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Taniguchi, Ryoji</au><au>Sato, Yukihito</au><au>Yamada, Tasuku</au><au>Ooba, Muneo</au><au>Higuchi, Hirokazu</au><au>Matsumori, Akira</au><au>Kimura, Takeshi</au><au>Kita, Toru</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined Measurements of Cardiac Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Patients With Heart Failure</atitle><jtitle>Circulation Journal</jtitle><addtitle>Circ J</addtitle><date>2004-12-01</date><risdate>2004</risdate><volume>68</volume><issue>12</issue><spage>1160</spage><epage>1164</epage><pages>1160-1164</pages><issn>1346-9843</issn><eissn>1347-4820</eissn><abstract>Background To examine the prognostic contribution of combined cardiac troponin T (cTnT) and N-terminal pro-brain natriuretic peptide (NT-proBNP) in patients with heart failure (CHF) in the absence of acute coronary syndrome. Methods and Results Between July 2001 and March 2002, 71 consecutive patients (mean age = 68.4±1.4 years, 37 men), hospitalised for heart failure, were studied during hospitalisation and follow up until December 2002. Serum cTnT and NT-proBNP were measured on admission. Actuarial rates of adverse cardiac events, including sudden or CHF death, or rehospitalisation for CHF during follow up were compared with patients grouped according to initial serum cTnT and/or NT-proBNP concentrations. The adverse cardiac event-free rate among the 20 patients with cTnT ≥0.01 ng/ml was significantly lower than the 51 patients with cTnT &lt;0.01 ng/ml (P&lt;0.05). Similarly, the adverse cardiac event-free rate among the 36 patients with NT-proBNP ≥1,357 pg/ml (median) was significantly lower than the 35 patients with NT-proBNP &lt;1,357 pg/ml (P&lt;0.01). The 16 patients with high concentrations of both cTnT and NT-proBNP had a lower adverse cardiac event-free rate than the 31 patients with low cTnT and low NT-proBNP upon commencement of the study (P&lt;0.005). Conclusion Measurements of serum cTnT and NT-proBNP were reliable prognostic markers of adverse cardiac event in patients with CHF. (Circ J 2004; 68: 1160 - 1164)</abstract><cop>Japan</cop><pub>The Japanese Circulation Society</pub><pmid>15564700</pmid><doi>10.1253/circj.68.1160</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record>
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ispartof Circulation Journal, 2004, Vol.68(12), pp.1160-1164
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source Freely Accessible Journals
subjects Aged
Cardiac Output, Low - blood
Cardiac Output, Low - complications
Cardiac Output, Low - metabolism
Cardiac Output, Low - mortality
Chronic Disease
Death, Sudden, Cardiac
Female
Follow-Up Studies
Heart Diseases - etiology
Heart Diseases - mortality
Heart failure
Humans
Male
Middle Aged
Myocardium - metabolism
Natriuretic Peptide, Brain
Nerve Tissue Proteins - blood
Nerve Tissue Proteins - metabolism
Patient Readmission - statistics & numerical data
Peptide Fragments - blood
Peptide Fragments - metabolism
Pro-brain natriuretic peptide
Prognosis
Troponin
Troponin T - blood
Troponin T - metabolism
title Combined Measurements of Cardiac Troponin T and N-Terminal Pro-Brain Natriuretic Peptide in Patients With Heart Failure
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