Design and optimization of selective serotonin re-uptake inhibitors with high synthetic accessibility Part 1

The reported selective serotonin Re-uptake Inhibitor (SSRI) litoxetine was used as the starting point in the design of a range of potent, selective SSRIs with high ease of synthetic accessibility. The reported selective serotonin Re-uptake Inhibitor Litoxetine was used as the starting point in the d...

Full description

Saved in:
Bibliographic Details
Published in:Bioorganic & medicinal chemistry letters 2009-04, Vol.19 (8), p.2329-2332
Main Authors: Andrews, Mark, Brown, Alan, Chiva, Jean-Yves, Fradet, David, Gordon, David, Lansdell, Mark, MacKenny, Malcolm
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Line
Drug Design
Humans
Medical sciences
Neuropharmacology
Neurotransmitters. Neurotransmission. Receptors
Pharmacology. Drug treatments
Piperidines - chemical synthesis
Piperidines - metabolism
Re-uptake
Seretonin
Serotonin Uptake Inhibitors - chemical synthesis
Serotonin Uptake Inhibitors - metabolism
Serotoninergic system
Structure-Activity Relationship
Transporter
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The reported selective serotonin Re-uptake Inhibitor (SSRI) litoxetine was used as the starting point in the design of a range of potent, selective SSRIs with high ease of synthetic accessibility. The reported selective serotonin Re-uptake Inhibitor Litoxetine was used as the starting point in the design of a range of potential SSRIs with high ease of synthetic accessibility. Preparation and subsequent optimization yielded a range of potent and highly selective SSRIs.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2009.02.054