Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran (MGN-3/Biobran)

The present study is aimed to examine the possibility of enhancement of natural killer (NK) cell activity in aged C57BL/6 and C3H mice using MGN‐3, a modified arabinoxylan from rice bran. Intraperitoneal injection of MGN‐3 (10 mg kg−1 per day) caused a remarkable increase in the peritoneal NK activi...

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Bibliographic Details
Published in:Journal of pharmacy and pharmacology 2004-12, Vol.56 (12), p.1581-1588
Main Authors: Ghoneum, Mamdooh, Abedi, Sarah
Format: Article
Language:English
Subjects:
Aging - drug effects
Aging - immunology
Animals
Cells, Cultured
Female
Immunologic Factors - isolation & purification
Immunologic Factors - pharmacology
Killer Cells, Natural - cytology
Killer Cells, Natural - drug effects
Killer Cells, Natural - metabolism
Lymphocyte Activation - drug effects
Lymphocyte Activation - physiology
Mice
Mice, Inbred C3H
Mice, Inbred C57BL
Oryza sativa
Xylans - isolation & purification
Xylans - pharmacology
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Summary:The present study is aimed to examine the possibility of enhancement of natural killer (NK) cell activity in aged C57BL/6 and C3H mice using MGN‐3, a modified arabinoxylan from rice bran. Intraperitoneal injection of MGN‐3 (10 mg kg−1 per day) caused a remarkable increase in the peritoneal NK activity as early as 2 days (35.2 lytic units), and the level remained elevated through day 14. The control aged mice had a level of 5.8 lytic units. Enhancement in NK activity was associated with an increase in both the binding capacity of NK cells to tumour targets and in the granular content as measured by BLT‐esterase activity. Treatment did not alter the percentage of peritoneal NK cells. Data showed that peritoneal macrophages inhibit NK activity. In conclusion, MGN‐3 enhances murine NK activity of aged mice and may be useful for enhancing NK function in aged humans.
ISSN:0022-3573
2042-7158
DOI:10.1211/0022357044922