Antimicrobial susceptibility of Streptococcus pyogenes in Central, Eastern, and Baltic European Countries, 2005 to 2006: the cefditoren surveillance program

Abstract The in vitro activity of penicillin, ampicillin, cefditoren, cefotaxime, erythromycin, clarithromycin, and levofloxacin against 763 clinical isolates of Streptococcus pyogenes was determined. Clinically significant isolates collected from November 2005 to December 2006 in the Czech Republic...

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Published in:Diagnostic microbiology and infectious disease 2009-05, Vol.64 (1), p.52-56
Main Authors: Gracia, Matilde, Díaz, Carolina, Coronel, Pilar, Gimeno, Mercedes, García-Rodas, Rocío, Rodríguez-Cerrato, Violeta, del Prado, Gema, Huelves, Lorena, Ruiz, Vicente, Naves, Plínio F.L, Ponte, Maria-Carmen, Granizo, Juan José, Soriano, Francisco
Format: Article
Language:English
Subjects:
Adult
Anti-Bacterial Agents - pharmacology
Antimicrobial susceptibility
Bacteriology
beta-Lactams - pharmacology
Biological and medical sciences
Cefditoren
Child
Drug Resistance, Bacterial
Europe
Female
Fundamental and applied biological sciences. Psychology
Humans
Infectious Disease
Infectious diseases
Internal Medicine
Levofloxacin
Macrolides
Macrolides - pharmacology
Male
Medical sciences
Microbial Sensitivity Tests
Microbiology
Miscellaneous
Ofloxacin - pharmacology
Streptococcal Infections - microbiology
Streptococcus pyogenes
Streptococcus pyogenes - drug effects
Streptococcus pyogenes - isolation & purification
Surveillance
Young Adult
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Summary:Abstract The in vitro activity of penicillin, ampicillin, cefditoren, cefotaxime, erythromycin, clarithromycin, and levofloxacin against 763 clinical isolates of Streptococcus pyogenes was determined. Clinically significant isolates collected from November 2005 to December 2006 in the Czech Republic, Slovakia, Hungary, Poland, Romania, Estonia, Latvia, and Lithuania (the latter 3 analyzed as Baltic countries) were studied. No resistance to β-lactams and levofloxacin was found. The rate of erythromycin resistance in S. pyogenes varied among countries, being low (25%) in Hungary and Slovakia. The predominant (75.0%) erythromycin-resistant phenotype among S. pyogenes isolates was MLSB . The identification of the prevalence of erythromycin resistance mechanism could have impact on the choice of empiric antibiotic therapy for the clinicians in such countries.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2008.12.018