A functional Ser(413)/Ser(413) PAI-2 polymorphism is associated with susceptibility and damage index score in systemic lupus erythematosus

Systemic lupus erythematosus in some cases is characterized for development of thrombotic events with a significantly increased risk of mortality. The frequencies and clinical associations of Ser(413)/Cys(413) PAI-2 polymorphism in 40 systemic lupus erythematosus, 50 rheumatoid arthritis patients, a...

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Published in:Clinical and applied thrombosis/hemostasis 2009-03, Vol.15 (2), p.233-238
Main Authors: Palafox-Sánchez, Claudia A, Vázquez-Del Mercado, Mónica, Orozco-Barocio, Gerardo, García-De la Torre, Ignacio, Torres-Carrillo, Norma, Torres-Carrillo, Nora M, Illades-Aguiar, Berenice, Muñoz-Valle, José F
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Alleles
Arthritis, Rheumatoid - blood
Arthritis, Rheumatoid - genetics
Arthritis, Rheumatoid - pathology
Case-Control Studies
Female
Genetic Predisposition to Disease
Genotype
Humans
Lupus Erythematosus, Systemic - blood
Lupus Erythematosus, Systemic - genetics
Lupus Erythematosus, Systemic - pathology
Male
Middle Aged
Plasminogen Activator Inhibitor 2 - genetics
Polymorphism, Genetic
Severity of Illness Index
Young Adult
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Summary:Systemic lupus erythematosus in some cases is characterized for development of thrombotic events with a significantly increased risk of mortality. The frequencies and clinical associations of Ser(413)/Cys(413) PAI-2 polymorphism in 40 systemic lupus erythematosus, 50 rheumatoid arthritis patients, and 100 healthy subjects were investigated. The Ser(413)/Ser(413) genotype frequency was 53% (lupus), 36% (rheumatoid arthritis), and 35% (healthy subjects). The Ser(413) allele was associated with systemic lupus erythematosus (P = .04, odds ratio = 1.76, 95% confidence interval = 1.01-3.06). In all, 4 patient carriers of Ser(413)/Ser(413) genotype, developed thrombotic events. The lupus patients identified with Ser( 413)/Ser(413) genotype showed an increased damage (57%), compared with Ser(413)/Cys(413) and Cys(413)/Cys(413) genotypes, with significant difference (P = .03). These findings suggest an association of Ser( 413) /Ser( 413) genotype with greater damage index score and Ser( 413) allele with systemic lupus erythematosus. Besides, PAI-2 polymorphism could be related with thrombotic phenomena in systemic lupus erythematosus.
ISSN:1076-0296
DOI:10.1177/1076029607308868