Haliclonin A, a New Macrocyclic Diamide from the Sponge Haliclona sp

Haliclonin A (1), a macrocyclic diamide of a novel skeletal class, was isolated from the marine sponge Haliclona sp. collected from Korean waters. The structure of this compound was determined using a combination of spectroscopic and chemical analyses. The new compound exhibited moderate cytotoxicit...

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Bibliographic Details
Published in:Organic letters 2009-04, Vol.11 (8), p.1713-1716
Main Authors: Jang, Kyoung Hwa, Kang, Gyoung Won, Jeon, Ju-eun, Lim, Chaemin, Lee, Hyi-Seung, Sim, Chung J, Oh, Ki-Bong, Shin, Jongheon
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemistry
Anti-Bacterial Agents - isolation & purification
Anti-Bacterial Agents - pharmacology
Antineoplastic Agents - chemistry
Antineoplastic Agents - isolation & purification
Antineoplastic Agents - pharmacology
Diamines - chemistry
Diamines - isolation & purification
Diamines - pharmacology
Drug Screening Assays, Antitumor
Haliclona - chemistry
Humans
K562 Cells
Macrocyclic Compounds - chemistry
Macrocyclic Compounds - isolation & purification
Macrocyclic Compounds - pharmacology
Marine Biology
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
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Summary:Haliclonin A (1), a macrocyclic diamide of a novel skeletal class, was isolated from the marine sponge Haliclona sp. collected from Korean waters. The structure of this compound was determined using a combination of spectroscopic and chemical analyses. The new compound exhibited moderate cytotoxicity and antibacterial activity against diverse microbial strains.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol900282m