Effects of thyroid hormone on serum glycated albumin levels: Study on non-diabetic subjects

Abstract Glycated albumin (GA) is used alongside glycated hemoglobin (HbA1C ) as an indicator of glycemic control. Although serum GA levels are affected mainly by plasma glucose, they are also influenced by serum albumin metabolism. Thyroid hormone is known to promote albumin catabolism, and it is t...

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Bibliographic Details
Published in:Diabetes research and clinical practice 2009-05, Vol.84 (2), p.163-167
Main Authors: Koga, M, Murai, J, Saito, H, Matsumoto, S, Kasayama, S
Format: Article
Language:English
Subjects:
Aged
Blood Glucose - metabolism
Endocrinology & Metabolism
Female
Glycated albumin
Glycated hemoglobin (HbA 1C)
Glycated Hemoglobin A - metabolism
Graves Disease - blood
Hashimoto Disease - blood
Humans
Hyperthyroidism - blood
Hypothyroidism
Male
Middle Aged
Reference Values
Serum Albumin - drug effects
Serum Albumin - metabolism
Thyroid Diseases - blood
Thyroid Diseases - drug therapy
Thyroid hormone
Thyrotoxicosis
Thyrotropin - blood
Thyroxine - blood
Thyroxine - therapeutic use
Triiodothyronine - blood
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Summary:Abstract Glycated albumin (GA) is used alongside glycated hemoglobin (HbA1C ) as an indicator of glycemic control. Although serum GA levels are affected mainly by plasma glucose, they are also influenced by serum albumin metabolism. Thyroid hormone is known to promote albumin catabolism, and it is thus thought to affect serum GA levels. In the present study, the effects of thyroid hormone on serum GA measurements were investigated in patients with thyroid dysfunction. Six patients with untreated hypothyroidism and 17 patients with untreated thyrotoxicosis were investigated. Patients who had anemia or diabetes were excluded. A total of 25 non-diabetic, euthyroid individuals were enrolled as controls. HbA1C , serum GA, thyroid-stimulating hormone (TSH), free triiodothyronine (T3 ), and free thyroxine (T4 ) levels were measured in all these subjects, and their relationships were examined. Although no intergroup differences were observed for HbA1C , serum GA was significantly higher among patients with hypothyroidism than controls, and significantly lower among patients with thyrotoxicosis. Serum GA had a significant positive correlation with serum TSH and significant inverse correlations with free T3 and free T4. Thyroid hormone levels are inversely associated with serum GA levels. Cautions are necessary when evaluating serum GA levels in patients with thyroid dysfunction.
ISSN:0168-8227
1872-8227
DOI:10.1016/j.diabres.2009.01.013