Hepatitis B reactivation in a hepatitis B surface antigen-negative patient after allogeneic bone marrow transplant: successful treatment with lamivudine and seroconversion

Abstract Hepatitis B reactivation in hepatitis B surface antigen (HBsAg)-negative and anti-HBsAg antibodies-positive patients is an infrequent complication of chemotherapy, usually with fatal evolution. Here we report an HBsAg-negative patient with a myelodysplastic syndrome, who developed hepatitis...

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Bibliographic Details
Published in:Diagnostic microbiology and infectious disease 2009-05, Vol.64 (1), p.80-82
Main Authors: PEREZ-GRANDE, Rosa, GUTIERREZ-ZUFIAURRE, Nieves, MUNOZ-CRIADO, Santiago, BLAZQUEZ DE CASTRO, Ana M, VAZQUEZ LOPEZ, Lourdes, SAN MARTIN, Francisco Gonzalez, GARCIA RODRIGUEZ, Jose Angel, MUNOZ BELLIDO, Juan Luis
Format: Article
Language:English
Subjects:
Adult
Antiviral Agents - therapeutic use
Biological and medical sciences
Bone Marrow Transplantation - adverse effects
Female
Fundamental and applied biological sciences. Psychology
Hepatitis B
Hepatitis B - diagnosis
Hepatitis B - drug therapy
Hepatitis B Antibodies - blood
Hepatitis B Surface Antigens - blood
Human viral diseases
Humans
Immunosuppression
Immunosuppressive Agents - adverse effects
Infectious Disease
Infectious diseases
Internal Medicine
Lamivudine
Lamivudine - therapeutic use
Medical sciences
Microbiology
Miscellaneous
Reactivation
Viral diseases
Viral hepatitis
Virology
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Summary:Abstract Hepatitis B reactivation in hepatitis B surface antigen (HBsAg)-negative and anti-HBsAg antibodies-positive patients is an infrequent complication of chemotherapy, usually with fatal evolution. Here we report an HBsAg-negative patient with a myelodysplastic syndrome, who developed hepatitis B reactivation after chemotherapy and evolved favorably after lamivudine treatment, allowing seroconversion.
ISSN:0732-8893
1879-0070
DOI:10.1016/j.diagmicrobio.2009.01.007