The association between pulse wave velocity and metabolic syndrome and adiponectin in patients with impaired fasting glucose: Cardiovascular risks and adiponectin in IFG

• Published in: Diabetes research and clinical practice 2009-05, Vol.84 (2), p.145-151
• Main Authors: Nam, J.S, Park, J.S, Cho, M.H, Jee, S.H, Lee, H.S, Ahn, C.W, Lowe, W.L, Kim, K.R
• Format: Article
• Language: English
• Subjects: Adiponectin; Adiponectin - blood; Adult; Blood Glucose - analysis; Blood Pressure; Cardiovascular Diseases - blood; Cardiovascular Diseases - epidemiology; Cholesterol - blood; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Cross-Sectional Studies; Endocrinology & Metabolism; Glucose Intolerance - blood; Glucose Intolerance - physiopathology; Humans; Impaired fasting glucose; Insulin - blood; Metabolic syndrome; Metabolic Syndrome - blood; Metabolic Syndrome - epidemiology; Metabolic Syndrome - physiopathology; Middle Aged; Peripheral Vascular Diseases - blood; Peripheral Vascular Diseases - epidemiology; Peripheral Vascular Diseases - physiopathology; Pulse; Pulse wave; Risk Factors
• ISSN: 0168-8227; 1872-8227
• DOI: 10.1016/j.diabres.2009.02.002

Abstract We aimed to assess how metabolic profiles, surrogate markers of insulin resistance, and subclinical atherosclerosis are interrelated in subjects with impaired fasting glucose (IFG) and investigate whether the diagnosis of metabolic syndrome (MetS) further increases the risk of cardiovascular disease among subjects already at risk. We analyzed 1739 Korean subjects with IFG. The parameters of MetS, plasma adiponectin level, and pulse wave velocity (PWV) were assessed. Subjects with MetS had unfavorable metabolic parameters, lower adiponectin level, and higher peripheral PWV compared to those without MetS. Adiponectin correlated with fasting glucose, waist circumference, triglyceride, HDL-cholesterol, BMI, HOMA-IR, and the number of MetS components. In addition to blood pressure, peripheral PWV was associated with triglyceride, waist circumference, and the number of MetS components while aortic PWV correlated positively with fasting plasma glucose. Multiple linear regression analysis revealed that adiponectin correlated with HDL-cholesterol, HOMA-IR, fasting glucose, waist circumference, and triglyceride, peripheral PWV with blood pressure, body mass index, waist circumference, and the number of MetS components, and aortic PWV with fasting plasma glucose. In subjects with IFG, concurrent MetS increases PWV and has an unfavorable effect on cardiovascular risks, and these risks were further increased by additional MetS components.