Differences in feedback- and inhibition-related neural activity in adult ADHD

The objective of this study was to examine response inhibition- and feedback-related neural activity in adults with attention deficit hyperactivity disorder (ADHD) using event-related functional MRI. Sixteen male adults with ADHD and 13 healthy/normal controls participated in this study and performe...

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Bibliographic Details
Published in:Brain and cognition 2009-06, Vol.70 (1), p.73-83
Main Authors: Dibbets, Pauline, Evers, Lisbeth, Hurks, Petra, Marchetta, Natalie, Jolles, Jelle
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Adults
Analysis of Variance
Attention
Attention Deficit Disorder with Hyperactivity - physiopathology
Attention Deficit Disorders
Attention deficit hyperactivity disorder
Biological and medical sciences
Brain - physiopathology
Brain Hemisphere Functions
Brain Mapping
Cognition - physiology
Control Groups
Diagnostic Tests
Executive control
Feedback
Feedback (Response)
Feedback - physiology
Functional MRI
Go/NoGo
Humans
Hyperactivity
Impulsive Behavior - physiopathology
Inhibition
Linear Models
Magnetic Resonance Imaging
Male
Males
Medical sciences
Miscellaneous
Neuroimaging
Neurology
Neuropsychological Tests
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Reaction Time
Response inhibition
Surveys and Questionnaires
Task Analysis
Task Performance and Analysis
Young Adult
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Summary:The objective of this study was to examine response inhibition- and feedback-related neural activity in adults with attention deficit hyperactivity disorder (ADHD) using event-related functional MRI. Sixteen male adults with ADHD and 13 healthy/normal controls participated in this study and performed a modified Go/NoGo task. Behaviourally, attention and inhibition problems in the ADHD group were observed; no feedback-related differences between the groups were detected. The neuroimaging data showed that the ADHD group displayed more activation in the inferior frontal gyrus and putamen during response inhibition. During feedback-related processes, the ADHD group displayed less activation in the inferior frontal/orbitofrontal cortex, hippocampus/nucleus accumbens, and caudate nucleus, but more activity in the inferior frontal gyrus. These results indicate that at least two distinguishable underlying brain networks related to response inhibition and feedback are altered in adults with ADHD.
ISSN:0278-2626
1090-2147
DOI:10.1016/j.bandc.2009.01.001