Dynamic perfusion patterns in temporal lobe epilepsy

Purpose To investigate dynamic ictal perfusion changes during temporal lobe epilepsy (TLE). Methods We investigated 37 patients with TLE by ictal and interictal SPECT. All ictal injections were performed within 60 s of seizure onset. Statistical parametric mapping was used to analyse brain perfusion...

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Bibliographic Details
Published in:European journal of nuclear medicine and molecular imaging 2009-05, Vol.36 (5), p.823-830
Main Authors: Dupont, Patrick, Zaknun, John J., Maes, Alex, Tepmongkol, Supatporn, Vasquez, Silvia, Bal, C. S., Van Paesschen, Wim, Carpintiero, Silvina, Locharernkul, Chaichon, Dondi, Maurizio
Format: Article
Language:English
Subjects:
Adolescent
Adult
Algorithms
Brain
Cardiology
Epilepsy
Epilepsy, Temporal Lobe - diagnosis
Epilepsy, Temporal Lobe - diagnostic imaging
Epilepsy, Temporal Lobe - pathology
Female
Humans
Imaging
Male
Medical imaging
Medicine
Medicine & Public Health
Middle Aged
Models, Statistical
Multivariate Analysis
Nuclear Medicine
Oncology
Original Article
Orthopedics
Perfusion
Physiology
Radiology
Seizures - diagnosis
Seizures - diagnostic imaging
Temporal Lobe - diagnostic imaging
Temporal Lobe - pathology
Time Factors
Tomography, Emission-Computed, Single-Photon - methods
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Summary:Purpose To investigate dynamic ictal perfusion changes during temporal lobe epilepsy (TLE). Methods We investigated 37 patients with TLE by ictal and interictal SPECT. All ictal injections were performed within 60 s of seizure onset. Statistical parametric mapping was used to analyse brain perfusion changes and temporal relationships with injection time and seizure duration as covariates. Results The analysis revealed significant ictal hyperperfusion in the ipsilateral temporal lobe extending to subcortical regions. Hypoperfusion was observed in large extratemporal areas. There were also significant dynamic changes in several extratemporal regions: ipsilateral orbitofrontal and bilateral superior frontal gyri and the contralateral cerebellum and ipsilateral striatum. Conclusion The study demonstrated early dynamic perfusion changes in extratemporal regions probably involved in both propagation of epileptic activity and initiation of inhibitory mechanisms.
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-008-1040-6