NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer

• Published in: Trends in biochemical sciences (Amsterdam. Regular ed.) 2009-04, Vol.34 (4), p.176-188
• Main Authors: Hayes, John D., McMahon, Michael
• Format: Article
• Language: English
• Subjects: Adaptation, Biological - genetics; Animals; Humans; Intracellular Signaling Peptides and Proteins - genetics; Intracellular Signaling Peptides and Proteins - metabolism; Models, Biological; Mutation - genetics; Neoplasms - genetics; Neoplasms - metabolism; NF-E2-Related Factor 2 - chemistry; NF-E2-Related Factor 2 - genetics; NF-E2-Related Factor 2 - metabolism
• ISSN: 0968-0004; 1362-4326
• DOI: 10.1016/j.tibs.2008.12.008

Transcription factor nuclear factor-erythroid 2-related factor 2 (NRF2) controls cellular adaptation to oxidants and electrophiles by inducing antioxidant and detoxification genes in response to redox stress. NRF2 is negatively regulated by Kelch-like ECH-associated protein 1 (KEAP1). Tumours from ∼15% of patients with lung cancer harbour somatic mutations in KEAP1 that prevent effective NRF2 repression. Recently, two NRF2 mutation ‘hot-spots’ were identified in ∼10% of patients with lung cancer, enabling the transcription factor to evade KEAP1-mediated repression. Somatic mutations in KEAP1 and NRF2 provide an insight into the molecular mechanisms by which NRF2 is regulated. Moreover, constitutive NRF2 activation might cause drug resistance in tumours, and an understanding of how the transcription factor is regulated indicates ways in which this could be overcome.