Effects of Darbepoetin Alfa on Plasma Mediators of Oxidative and Nitrosative Stress in Anemic Patients With Chronic Heart Failure Secondary to Ischemic or Idiopathic Dilated Cardiomyopathy

Increased oxidative and nitrosative stress are important mediators of left ventricular (LV) and vascular dysfunction in patients with chronic heart failure (CHF). This study investigated the effects of darbepoetin alfa on plasma markers of oxidative and nitrosative stress in patients with CHF with a...

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Bibliographic Details
Published in:The American journal of cardiology 2009-04, Vol.103 (8), p.1134-1138
Main Authors: Parissis, John T., MD, Kourea, Kallirrhoe, MD, Andreadou, Ioanna, MS, PhD, Ikonomidis, Ignatios, MD, Markantonis, Sophia, MS, PhD, Ioannidis, Konstadinos, MS, Paraskevaidis, Ioannis, MD, Iliodromitis, Efstathios, MD, Filippatos, Gerasimos, MD, Kremastinos, Dimitrios Th., MD
Format: Article
Language:English
Subjects:
Aged
Anemia
Anemia - blood
Anemia - metabolism
Anemia - physiopathology
Anemias. Hemoglobinopathies
Biological and medical sciences
Cardiology
Cardiology. Vascular system
Cardiomyopathies - complications
Cardiovascular
Chronic Disease
Darbepoetin alfa
Diseases of red blood cells
Erythropoietin - analogs & derivatives
Erythropoietin - pharmacology
Exercise Tolerance - drug effects
Female
Heart
Heart failure
Heart Failure - blood
Heart Failure - etiology
Heart Failure - metabolism
Heart Failure - physiopathology
Heart failure, cardiogenic pulmonary edema, cardiac enlargement
Hematinics - pharmacology
Hematologic and hematopoietic diseases
Humans
Male
Medical sciences
Middle Aged
Myocarditis. Cardiomyopathies
Nitrosation - drug effects
Oxidation
Oxidative Stress - drug effects
Studies
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Summary:Increased oxidative and nitrosative stress are important mediators of left ventricular (LV) and vascular dysfunction in patients with chronic heart failure (CHF). This study investigated the effects of darbepoetin alfa on plasma markers of oxidative and nitrosative stress in patients with CHF with anemia. Thirty patients with CHF (LV ejection fraction [LVEF]
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2008.12.041