Long-Term Follow-Up of Patients with Fulminant Clostridium difficile Colitis

Purpose The purpose of this study was to determine the long-term survival rate, rate of gastrointestinal continuity restoration, and rate of recurrence following an attack of fulminant Clostridium difficile colitis. Material and Methods Fulminant C. difficile colitis was defined as any patient who h...

Full description

Saved in:
Bibliographic Details
Published in:Journal of gastrointestinal surgery 2009-05, Vol.13 (5), p.956-959
Main Authors: Miller, Aaron T., Tabrizian, Parissa, Greenstein, Alexander J., Dikman, Andrew, Byrn, John, Divino, Celia
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Anti-Bacterial Agents - therapeutic use
Clostridioides difficile
Colectomy
Colostomy
Disease-Free Survival
Enterocolitis, Pseudomembranous - diagnosis
Enterocolitis, Pseudomembranous - mortality
Enterocolitis, Pseudomembranous - therapy
Female
Follow-Up Studies
Gastroenterology
Humans
Ileostomy
Inflammatory bowel disease
Male
Medical research
Medicine
Medicine & Public Health
Middle Aged
Mortality
Original Article
Surgery
Survival Rate
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Purpose The purpose of this study was to determine the long-term survival rate, rate of gastrointestinal continuity restoration, and rate of recurrence following an attack of fulminant Clostridium difficile colitis. Material and Methods Fulminant C. difficile colitis was defined as any patient who had a bout of C. difficile colitis and required surgical intervention after failing medical therapy. These patients were found through a pathological database search. Follow-up phone calls were made to any patient who survived at least 30 days after being discharged from the hospital following surgical intervention (long-term survivor group). Results A total of 49 patients were involved in the study. The 30-day mortality rate was 57% (28/49), with an in-hospital mortality rate of 49%. The 5-year survival rate for the long-term survival group was 38% (8/21) and 16.3% for all patients. Gastrointestinal continuity was restored in 20% of the patients. There was one documented recurrence of C. difficile colitis Conclusion Patients who have a bout of fulminant C. difficile colitis have a poor prognosis of surviving longer than 5 years. Restoring gastrointestinal continuity is uncommon and usually reserved for patients with few co-morbidities. Recurrent C. difficile colitis after surgical resection is a rare occurrence
ISSN:1091-255X
1873-4626
DOI:10.1007/s11605-009-0819-5