CD154 and its receptors in inflammatory vascular pathologies

CD154, a member of the tumor necrosis factor-α family, has recently been implicated in the pathophysiology of vascular diseases. Indeed, blockade of CD154 by neutralizing antibodies or genetic disruption in mice prevents atherosclerosis and atherothrombosis. CD154 is believed to interact mainly via...

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Bibliographic Details
Published in:Trends in immunology 2009-04, Vol.30 (4), p.165-172
Main Authors: Hassan, Ghada S, Merhi, Yahye, Mourad, Walid M
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies, Monoclonal - immunology
Antibodies, Monoclonal - therapeutic use
Atherosclerosis
Atherosclerosis - immunology
Atherosclerosis - pathology
Atherosclerosis - physiopathology
Atherosclerosis - therapy
Biological activity
CD4-Positive T-Lymphocytes - immunology
CD4-Positive T-Lymphocytes - metabolism
CD4-Positive T-Lymphocytes - pathology
CD40 Antigens - immunology
CD40 Antigens - metabolism
CD40 Ligand - antagonists & inhibitors
CD40 Ligand - genetics
CD40 Ligand - immunology
CD40 Ligand - metabolism
Cytokines
Humans
Immune system
Immunotherapy
Integrin alpha5beta1 - immunology
Integrin alpha5beta1 - metabolism
Ligands
Macrophage-1 Antigen - immunology
Macrophage-1 Antigen - metabolism
Medical research
Mice
Neovascularization, Pathologic - immunology
Neovascularization, Pathologic - therapy
Platelet Activation
Platelet Glycoprotein GPIIb-IIIa Complex - immunology
Platelet Glycoprotein GPIIb-IIIa Complex - metabolism
Signal Transduction - immunology
Studies
Vasa Vasorum - immunology
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Description
Summary:CD154, a member of the tumor necrosis factor-α family, has recently been implicated in the pathophysiology of vascular diseases. Indeed, blockade of CD154 by neutralizing antibodies or genetic disruption in mice prevents atherosclerosis and atherothrombosis. CD154 is believed to interact mainly via the CD40 receptor, however, it has also been found to bind with αIIbβ3 integrin and so induces platelet activation. Moreover, we (and others) have recently identified the integrins α5β1 and Mac-1 as novel CD154 receptors expressed on many cell types. Here, we illustrate the various functional features of these molecules, while describing the increasingly important role of CD40 in CD154-associated vascular pathologies such as atherosclerosis and atherothrombosis.
ISSN:1471-4906
1471-4981
DOI:10.1016/j.it.2009.01.004