Highly Stable Indomethacin Glasses Resist Uptake of Water Vapor

Mass uptake of water vapor was measured as a function of relative humidity for indomethacin glasses prepared using physical vapor deposition at different substrate temperatures. Highly stable glasses were produced on substrates at 265 K (0.84T g) by depositing at 0.2 nm/s while samples similar to me...

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Bibliographic Details
Published in:The journal of physical chemistry. B 2009-02, Vol.113 (8), p.2422-2427
Main Authors: Dawson, Kevin J, Kearns, Kenneth L, Ediger, M. D, Sacchetti, Mark J, Zografi, George D
Format: Article
Language:English
Subjects:
B: Statistical Mechanics, Thermodynamics, Medium Effects
Diffusion
Glass - chemistry
Indomethacin - chemistry
Temperature
Water - chemistry
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Summary:Mass uptake of water vapor was measured as a function of relative humidity for indomethacin glasses prepared using physical vapor deposition at different substrate temperatures. Highly stable glasses were produced on substrates at 265 K (0.84T g) by depositing at 0.2 nm/s while samples similar to melt-cooled glasses were produced at 315 K and 5 nm/s. Samples deposited at 315 K absorb approximately the same amount of water as glasses prepared by supercooling the melt while stable glasses absorb a factor of 5 less water. Unexpectedly, the diffusion of water in the stable glass samples is 5−10 times faster than in the glass prepared by cooling the liquid.
ISSN:1520-6106
1520-5207
DOI:10.1021/jp808838t