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Prognostic factors for the malignant triton tumor of the head and neck
Background. Malignant triton tumors are rare neoplasias consisting of a malignant peripheral nerve sheath tumor with additional rhabdomyoblastic differentiation. These tumors are highly aggressive and prognosis is poor. Our aim is to describe the outcome and to identify potential prognostic factors....
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| Published in: | Head & neck 2009-05, Vol.31 (5), p.679-688 |
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| Main Authors: | , , , |
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| Language: | English |
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| container_end_page | 688 |
| container_issue | 5 |
| container_start_page | 679 |
| container_title | Head & neck |
| container_volume | 31 |
| creator | Terzic, Andrej Bode, Beata Gratz, Klaus W. Stoeckli, Sandro J. |
| description | Background.
Malignant triton tumors are rare neoplasias consisting of a malignant peripheral nerve sheath tumor with additional rhabdomyoblastic differentiation. These tumors are highly aggressive and prognosis is poor. Our aim is to describe the outcome and to identify potential prognostic factors.
Methods.
From 1993 to 2005, 7 patients with a malignant triton tumor of the head and neck were treated at our institution. A literature search revealed another 46 published cases. All these cases were analyzed for outcome and prognostic factors.
Results.
Patients with primary tumors involving the nose and paranasal sinuses have better, patients involving the neck a poor prognosis. All other locations show an intermediate course. Complete surgical removal is of crucial importance. Additional radiation or chemotherapy show little effect.
Conclusion.
Location of the primary tumor is a key factor for prognosis. Complete surgical removal is the only treatment associated with survival.© 2009 Wiley Periodicals, Inc. Head Neck, 2009 |
| doi_str_mv | 10.1002/hed.21051 |
| format | article |
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Malignant triton tumors are rare neoplasias consisting of a malignant peripheral nerve sheath tumor with additional rhabdomyoblastic differentiation. These tumors are highly aggressive and prognosis is poor. Our aim is to describe the outcome and to identify potential prognostic factors.
Methods.
From 1993 to 2005, 7 patients with a malignant triton tumor of the head and neck were treated at our institution. A literature search revealed another 46 published cases. All these cases were analyzed for outcome and prognostic factors.
Results.
Patients with primary tumors involving the nose and paranasal sinuses have better, patients involving the neck a poor prognosis. All other locations show an intermediate course. Complete surgical removal is of crucial importance. Additional radiation or chemotherapy show little effect.
Conclusion.
Location of the primary tumor is a key factor for prognosis. Complete surgical removal is the only treatment associated with survival.© 2009 Wiley Periodicals, Inc. Head Neck, 2009</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.21051</identifier><identifier>PMID: 19283843</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Female ; Head and Neck Neoplasms - mortality ; Head and Neck Neoplasms - pathology ; Head and Neck Neoplasms - therapy ; Humans ; Male ; malignant peripheral nerve sheath tumor ; malignant triton tumor ; Medical sciences ; Middle Aged ; Nerve Sheath Neoplasms - mortality ; Nerve Sheath Neoplasms - pathology ; Nerve Sheath Neoplasms - therapy ; Neurology ; Otorhinolaryngology. Stomatology ; Prognosis ; rhabdomyoblastic differentiation ; Survival Analysis ; treatment ; Tumors of the nervous system. Phacomatoses</subject><ispartof>Head & neck, 2009-05, Vol.31 (5), p.679-688</ispartof><rights>Copyright © 2009 Wiley Periodicals, Inc.</rights><rights>2009 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3911-7d1515b99ac432b0bf3456326cc78f83629c95bc8648f5bae574553b38c30a9a3</citedby><cites>FETCH-LOGICAL-c3911-7d1515b99ac432b0bf3456326cc78f83629c95bc8648f5bae574553b38c30a9a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21325617$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19283843$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Terzic, Andrej</creatorcontrib><creatorcontrib>Bode, Beata</creatorcontrib><creatorcontrib>Gratz, Klaus W.</creatorcontrib><creatorcontrib>Stoeckli, Sandro J.</creatorcontrib><title>Prognostic factors for the malignant triton tumor of the head and neck</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background.
Malignant triton tumors are rare neoplasias consisting of a malignant peripheral nerve sheath tumor with additional rhabdomyoblastic differentiation. These tumors are highly aggressive and prognosis is poor. Our aim is to describe the outcome and to identify potential prognostic factors.
Methods.
From 1993 to 2005, 7 patients with a malignant triton tumor of the head and neck were treated at our institution. A literature search revealed another 46 published cases. All these cases were analyzed for outcome and prognostic factors.
Results.
Patients with primary tumors involving the nose and paranasal sinuses have better, patients involving the neck a poor prognosis. All other locations show an intermediate course. Complete surgical removal is of crucial importance. Additional radiation or chemotherapy show little effect.
Conclusion.
Location of the primary tumor is a key factor for prognosis. Complete surgical removal is the only treatment associated with survival.© 2009 Wiley Periodicals, Inc. Head Neck, 2009</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Female</subject><subject>Head and Neck Neoplasms - mortality</subject><subject>Head and Neck Neoplasms - pathology</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Humans</subject><subject>Male</subject><subject>malignant peripheral nerve sheath tumor</subject><subject>malignant triton tumor</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Nerve Sheath Neoplasms - mortality</subject><subject>Nerve Sheath Neoplasms - pathology</subject><subject>Nerve Sheath Neoplasms - therapy</subject><subject>Neurology</subject><subject>Otorhinolaryngology. Stomatology</subject><subject>Prognosis</subject><subject>rhabdomyoblastic differentiation</subject><subject>Survival Analysis</subject><subject>treatment</subject><subject>Tumors of the nervous system. Phacomatoses</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNp1kM1OwzAQhC0E4qdw4AVQLiBxCNheO46PqAWKVAESII6W49o0kMRguwLenpSW3jjtaufbHe0gdEjwGcGYns_s9IwSzMkG2iVYihwDE5uLnkEOWLAdtBfjK8YYCka30Q6RtISSwS66ug_-pfMx1SZz2iQfYuZ8yNLMZq1u6pdOdylLoU6-y9K87SXvftWZ1dNMd9Oss-ZtH2053UR7sKoD9HR1-Tgc55O765vhxSQ3IAnJxZRwwisptWFAK1w5YLwAWhgjSldCQaWRvDJlwUrHK225YJxDBaUBrKWGATpZ3n0P_mNuY1JtHY1tGt1ZP4-qEIRSKUQPni5BE3yMwTr1HupWh29FsFqEpvrQ1G9oPXu0Ojqv2n66Jlcp9cDxCtDR6MYF3Zk6rjlKgPKCLEzPl9xn3djv_x3V-HL0Z50vN-qY7Nd6Q4e3_hUQXD3fXqtRORxOHh8mSsIPPBWQaQ</recordid><startdate>200905</startdate><enddate>200905</enddate><creator>Terzic, Andrej</creator><creator>Bode, Beata</creator><creator>Gratz, Klaus W.</creator><creator>Stoeckli, Sandro J.</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>200905</creationdate><title>Prognostic factors for the malignant triton tumor of the head and neck</title><author>Terzic, Andrej ; Bode, Beata ; Gratz, Klaus W. ; Stoeckli, Sandro J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3911-7d1515b99ac432b0bf3456326cc78f83629c95bc8648f5bae574553b38c30a9a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Female</topic><topic>Head and Neck Neoplasms - mortality</topic><topic>Head and Neck Neoplasms - pathology</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Humans</topic><topic>Male</topic><topic>malignant peripheral nerve sheath tumor</topic><topic>malignant triton tumor</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Nerve Sheath Neoplasms - mortality</topic><topic>Nerve Sheath Neoplasms - pathology</topic><topic>Nerve Sheath Neoplasms - therapy</topic><topic>Neurology</topic><topic>Otorhinolaryngology. Stomatology</topic><topic>Prognosis</topic><topic>rhabdomyoblastic differentiation</topic><topic>Survival Analysis</topic><topic>treatment</topic><topic>Tumors of the nervous system. Phacomatoses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Terzic, Andrej</creatorcontrib><creatorcontrib>Bode, Beata</creatorcontrib><creatorcontrib>Gratz, Klaus W.</creatorcontrib><creatorcontrib>Stoeckli, Sandro J.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Terzic, Andrej</au><au>Bode, Beata</au><au>Gratz, Klaus W.</au><au>Stoeckli, Sandro J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic factors for the malignant triton tumor of the head and neck</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2009-05</date><risdate>2009</risdate><volume>31</volume><issue>5</issue><spage>679</spage><epage>688</epage><pages>679-688</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background.
Malignant triton tumors are rare neoplasias consisting of a malignant peripheral nerve sheath tumor with additional rhabdomyoblastic differentiation. These tumors are highly aggressive and prognosis is poor. Our aim is to describe the outcome and to identify potential prognostic factors.
Methods.
From 1993 to 2005, 7 patients with a malignant triton tumor of the head and neck were treated at our institution. A literature search revealed another 46 published cases. All these cases were analyzed for outcome and prognostic factors.
Results.
Patients with primary tumors involving the nose and paranasal sinuses have better, patients involving the neck a poor prognosis. All other locations show an intermediate course. Complete surgical removal is of crucial importance. Additional radiation or chemotherapy show little effect.
Conclusion.
Location of the primary tumor is a key factor for prognosis. Complete surgical removal is the only treatment associated with survival.© 2009 Wiley Periodicals, Inc. Head Neck, 2009</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>19283843</pmid><doi>10.1002/hed.21051</doi><tpages>10</tpages></addata></record> |
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| language | eng |
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| subjects | Adult Aged Biological and medical sciences Female Head and Neck Neoplasms - mortality Head and Neck Neoplasms - pathology Head and Neck Neoplasms - therapy Humans Male malignant peripheral nerve sheath tumor malignant triton tumor Medical sciences Middle Aged Nerve Sheath Neoplasms - mortality Nerve Sheath Neoplasms - pathology Nerve Sheath Neoplasms - therapy Neurology Otorhinolaryngology. Stomatology Prognosis rhabdomyoblastic differentiation Survival Analysis treatment Tumors of the nervous system. Phacomatoses |
| title | Prognostic factors for the malignant triton tumor of the head and neck |
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