The mechanism and significance of the slow changes of ventricular action potential duration following a change of heart rate

This article reviews the effects of changes of heart rate on the ventricular action potential duration. These can be divided into short term (fractions of a second), resulting from the kinetics of recovery of membrane currents, through to long term (up to days), resulting from changes of protein exp...

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Bibliographic Details
Published in:Experimental physiology 2009-05, Vol.94 (5), p.520-528
Main Authors: Eisner, D. A., Dibb, K. M., Trafford, A. W.
Format: Article
Language:English
Subjects:
Action Potentials
Animals
Calcium Channels, L-Type - metabolism
Calcium Signaling
Electrophysiological Phenomena
Heart - physiology
Heart Rate - physiology
Heart Ventricles - metabolism
Humans
In Vitro Techniques
Ion Channels - metabolism
Models, Cardiovascular
Sodium-Calcium Exchanger - metabolism
Sodium-Potassium-Exchanging ATPase - metabolism
Time Factors
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Summary:This article reviews the effects of changes of heart rate on the ventricular action potential duration. These can be divided into short term (fractions of a second), resulting from the kinetics of recovery of membrane currents, through to long term (up to days), resulting from changes of protein expression. We concentrate on the medium-term changes (time course of the order of 100 s). These medium-term changes occur in isolated tissues and in the intact human heart. They may protect against cardiac arrhythmias. Finally, we discuss the cellular mechanisms responsible for these changes.
ISSN:0958-0670
1469-445X
DOI:10.1113/expphysiol.2008.044008