Isolation of Cytochrome P450 Inhibitors from Strawberry Fruit, Fragaria ananassa

A new glycoside, 2-β-d-glucopyranosyloxy-4,6-dihydroxyisovalerophenone (3), was isolated from strawberry fruit along with kaempferol-3-β-d-(6-O-trans-p-coumaroyl)glucopyranoside (1) and kaempferol-3-β-d-(6-O-cis-p-coumaroyl)glucopyranoside (2). Compounds 1 and 2 inhibited activity of a drug-metaboli...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2004-11, Vol.67 (11), p.1839-1841
Main Authors: Tsukamoto, Sachiko, Tomise, Kyoko, Aburatani, Maki, Onuki, Hiroyuki, Hirorta, Hiroshi, Ishiharajima, Eiji, Ohta, Tomihisa
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme Inhibitors
Enzyme Inhibitors - chemistry
Enzyme Inhibitors - isolation & purification
Enzyme Inhibitors - pharmacology
Fragaria - chemistry
Fruit - chemistry
General pharmacology
Glycosides - chemistry
Glycosides - isolation & purification
Glycosides - pharmacology
Kaempferols - chemistry
Kaempferols - isolation & purification
Kaempferols - pharmacology
Medical sciences
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Pharmacognosy. Homeopathy. Health food
Pharmacology. Drug treatments
Plants, Medicinal - chemistry
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Summary:A new glycoside, 2-β-d-glucopyranosyloxy-4,6-dihydroxyisovalerophenone (3), was isolated from strawberry fruit along with kaempferol-3-β-d-(6-O-trans-p-coumaroyl)glucopyranoside (1) and kaempferol-3-β-d-(6-O-cis-p-coumaroyl)glucopyranoside (2). Compounds 1 and 2 inhibited activity of a drug-metabolizing enzyme, CYP3A4.
ISSN:0163-3864
1520-6025
DOI:10.1021/np0400104