Autoantibodies to Glutamate Receptors and Products of Nitric Oxide Metabolism in Serum in Children in the Acute Phase of Craniocerebral Trauma

Levels of serum autoantibodies (aAb) to glutamate receptors and products of nitric oxide (NO) metabolism, i.e., nitrates and nitrites, were assayed in children with recent craniocerebral trauma (CCT) of different levels of severity. All the children showed increases in serum aAb to both AMPA and NMD...

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Published in:Neuroscience and behavioral physiology 2009-05, Vol.39 (4), p.329-334
Main Authors: Sorokina, E. G., Semenova, Zh. B., Bazarnaya, N. A., Meshcheryakov, S. V., Reutov, V. P., Goryunova, A. V., Pinelis, V. G., Granstrem, O. K., Roshal, L. M.
Format: Article
Language:English
Subjects:
Autoantibodies - blood
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Brain damage
Brain Injuries - blood
Brain Injuries - diagnostic imaging
Brain Injuries - immunology
Brain research
Child
Childrens health
Female
Glasgow Coma Scale
Humans
Hypoxia
Immunology
Male
Metabolism
Metabolites
Neurobiology
Neurosciences
Nitrates
Nitrates - blood
Nitric oxide
Nitric Oxide - metabolism
Nitrites - blood
Pathogenesis
Pediatrics
Peptides
Permeability
Receptors, Glutamate - immunology
Receptors, N-Methyl-D-Aspartate - immunology
Surgery
Time Factors
Tomography, X-Ray Computed
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Summary:Levels of serum autoantibodies (aAb) to glutamate receptors and products of nitric oxide (NO) metabolism, i.e., nitrates and nitrites, were assayed in children with recent craniocerebral trauma (CCT) of different levels of severity. All the children showed increases in serum aAb to both AMPA and NMDA receptor subtypes from day 1 to day 10 after trauma. The highest levels of serum aAb were to the NMDA subtype of glutamate receptor, which was characteristic of children with mild CCT (MCCT), with Glasgow Coma Scale (GCS) scores of 14–15 points. Levels of aAb to NMDA (NR2A) receptors in children with severe CCT (SCCT, GCS 
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-009-9147-1