Pd-Catalyzed Amination of Nucleoside Arylsulfonates to yield N6-Aryl-2,6-Diaminopurine Nucleosides

Substituents on both the nucleoside arylsulfonate as well as the aryl amine component have a significant impact on their coupling to form 2,6‐diaminopurine‐2′‐deoxyribonucleosides (see scheme). A systematic study of ligands for the Pd catalysts in amination and CC cross‐coupling reactions gives ins...

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Published in:Angewandte Chemie International Edition 2004-11, Vol.43 (46), p.6372-6377
Main Authors: Gunda, Padmaja, Russon, Larry M., Lakshman, Mahesh K.
Format: Article
Language:English
Subjects:
Amination
Arylsulfonates - chemistry
Catalysis
CC coupling
Ligands
Molecular Structure
nucleosides
Nucleosides - chemistry
palladium
Palladium - chemistry
phosphane ligands
Purines - chemistry
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container_issue 46
container_start_page 6372
container_title Angewandte Chemie International Edition
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creator Gunda, Padmaja
Russon, Larry M.
Lakshman, Mahesh K.
description Substituents on both the nucleoside arylsulfonate as well as the aryl amine component have a significant impact on their coupling to form 2,6‐diaminopurine‐2′‐deoxyribonucleosides (see scheme). A systematic study of ligands for the Pd catalysts in amination and CC cross‐coupling reactions gives insight into the structural elements that lead to effective catalysis.
doi_str_mv 10.1002/anie.200460782
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subjects Amination
Arylsulfonates - chemistry
Catalysis
CC coupling
Ligands
Molecular Structure
nucleosides
Nucleosides - chemistry
palladium
Palladium - chemistry
phosphane ligands
Purines - chemistry
title Pd-Catalyzed Amination of Nucleoside Arylsulfonates to yield N6-Aryl-2,6-Diaminopurine Nucleosides
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