A comparison of cortical and trabecular bone from C57 Black 6 mice using Raman spectroscopy

Abstract Cortical and trabecular bone are both produced and maintained by the same cell types. At the microscopic scale they have a similar lamellar structure but at a macroscopic scale they are very different. Raman microscopy has been used to investigate compositional differences in the two bone t...

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Bibliographic Details
Published in:Bone (New York, N.Y.) N.Y.), 2009-05, Vol.44 (5), p.899-907
Main Authors: Goodyear, Simon R, Gibson, Iain R, Skakle, Janet M.S, Wells, Richard P.K, Aspden, Richard M
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Bone and Bones - chemistry
Bone and Bones - metabolism
Carbonates - metabolism
Composition
Cortical bone
Fundamental and applied biological sciences. Psychology
Male
Mice
Mice, Inbred C57BL
Mouse
Orthopedics
Phosphates - metabolism
Principal Component Analysis
Raman spectroscopy
Spectrum Analysis, Raman - methods
Trabecular bone
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:Abstract Cortical and trabecular bone are both produced and maintained by the same cell types. At the microscopic scale they have a similar lamellar structure but at a macroscopic scale they are very different. Raman microscopy has been used to investigate compositional differences in the two bone types using bone from standard laboratory mice in physiological conditions. Clear differences were observed when complete spectra were compared by principal component analysis (PCA). Analysis of individual bands showed cortical bone to have compositional characteristics of older bone when compared with trabecular material, possibly due to the higher bone turnover traditionally reported in the trabecular compartment.
ISSN:8756-3282
1873-2763
DOI:10.1016/j.bone.2009.01.008