Stress modulating antioxidant effect of Nardostachys jatamansi

The rhizomes of Nardostachysjatamansi, the plant commonly known as Jatamansi have been described in Ayurveda for their soothing and sedative action on the central nervous system. In the present study, the anti-stress effect of hydroethanolic extract (70%) of N. jatamansi (NJE) was evaluated in refer...

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Bibliographic Details
Published in:Indian journal of biochemistry & biophysics 2009-02, Vol.46 (1), p.93-98
Main Authors: Lyle, Nazmun, Bhattacharyya, Dipankar, Sur, Tapas K, Munshi, Santanu, Paul, Suhrita, Chatterjee, Suparna, Gomes, Antony
Format: Article
Language:English
Subjects:
Adrenal Glands - drug effects
Adrenal Glands - pathology
Adrenal Glands - physiopathology
Animals
Antioxidants - therapeutic use
Ascorbic Acid - metabolism
Brain - drug effects
Brain - physiopathology
Catalase - metabolism
Corticosterone - blood
Dose-Response Relationship, Drug
Free Radicals - metabolism
Lipid Peroxidation - physiology
Male
Nardostachys
Nitric Oxide - metabolism
Phytotherapy
Plant Extracts - therapeutic use
Rats
Rats, Wistar
Restraint, Physical
Spleen - drug effects
Spleen - pathology
Stomach - drug effects
Stomach - pathology
Stomach - physiopathology
Stress, Psychological - drug therapy
Stress, Psychological - pathology
Ulcer - drug therapy
Ulcer - pathology
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Summary:The rhizomes of Nardostachysjatamansi, the plant commonly known as Jatamansi have been described in Ayurveda for their soothing and sedative action on the central nervous system. In the present study, the anti-stress effect of hydroethanolic extract (70%) of N. jatamansi (NJE) was evaluated in reference to its antioxidant property. Wistar rats were divided into four groups: naive, stressed, and T-200 and T-500 stressed with oral pre-treatment of NJE 200 and 500 mg/kg, respectively. Restraint of rats in metallic chambers for 4 h at 4 degreesC was followed by sacrifice and assessment of stress-induced alterations in biochemical parameters, incidence and severity of ulcers. Lipid peroxidation (LPO) and NO levels in stomach and LPO, NO levels and catalase activity in brain, plasma corticosterone level and adrenal ascorbic acid were measured. In vitro antioxidant activity of NJE was studied by measuring the free radical scavenging activity. NJE showed potent antioxidant activity and significantly reversed the stress-induced elevation of LPO and NO levels and decrease in catalase activity in the brain. It inhibited the incidence of gastric ulcerations and reversed the alterations in biochemical parameters/markers of stress-induced gastric ulceration. NJE also significantly altered stress-induced increase in adrenal and spleen weights and decrease in level of ascorbic acid in adrenal gland. Elevation of plasma corticosterone level was negated dose- dependently. The findings suggest that the NJE possesses significant anti-stress activity, which may be due to its antioxidant activity.
ISSN:0301-1208