Higher level gait disorders in subcortical chronic vascular encephalopathy: a single photon emission computed tomography study

• Published in: Age and ageing 2009-05, Vol.38 (3), p.302-307
• Main Authors: Carboncini, Maria Chiara, Volterrani, Duccio, Bonfiglio, Luca, Barsotti, Gabriele, Porta, Mauro Della, Mariani, Giuliano, Rossi, Bruno
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Blood flow; Brain; Brain Mapping - methods; Cardiology; Cerebellum - blood supply; Cerebrovascular Circulation; cerebrovascular disease; Cysteine - analogs & derivatives; Dementia, Vascular - complications; Dementia, Vascular - diagnostic imaging; Dementia, Vascular - physiopathology; Elderly; Encephalopathy; Female; Frontal Lobe - blood supply; Gait; Gait Apraxia - diagnostic imaging; Gait Apraxia - etiology; Gait Apraxia - physiopathology; Gait disorders; higher level gait disorders; Humans; Male; Middle Aged; Motor ability; Neurology; Organotechnetium Compounds; Physiological aspects; Psychological aspects; Radiopharmaceuticals; Regional variations; SPECT; Tomography; Tomography, Emission-Computed, Single-Photon; Walking
• ISSN: 0002-0729; 1468-2834
• DOI: 10.1093/ageing/afp003

Background: the so-called higher level gait disorders include several types of gait disorders in which there are no major modifications in strength, tone, sensitivity, coordination and balance. Brain activation sites related to walking have been investigated using SPECT in humans. The aim of the study was to investigate brain activation during walking in subjects with high-level gait disorders due to chronic subcortical vascular encephalopathy. Subjects: twelve patients with a chronic vascular encephalopathy were enrolled in the study. Seven subjects had apraxic gait while in the other five the gait was normal. All patients had undergone a recent cerebral magnetic resonance that revealed diffused chronic ischemic lesions within the white matter. Methods: all 12 patients underwent a regional cerebral blood flow (rCBF) brain SPECT study with 99mTc-Bicisate on two separate days and under two different conditions: at rest (baseline) and while walking (functional). Results: the rCBF increase induced by the treadmill test (functional–baseline), bilaterally in the medial frontal gyrus and in the anterior lobes of the cerebellum, resulted significantly (P < 0.001) lower in patients with gait apraxia versus those without it. Conclusions: this study of the brain with SPECT records the areas of perfusion deficit that appear in apraxic subjects when they walk, compared with the recordings obtained with the same investigation performed at rest.