Long-term persistence of clonally expanded T cells in patients with polymyositis

Polymyositis is a CD8+ T‐cell–mediated disease. T‐cell clonal expansions are observed at disease onset, but little is known about their persistence over time. Qualitative and quantitative spectratyping demonstrated that PM relapse features dramatically perturbed blood T‐cell repertoires but is not a...

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Bibliographic Details
Published in:Annals of neurology 2004-12, Vol.56 (6), p.867-872
Main Authors: Benveniste, Olivier, Herson, Serge, Salomon, Benoît, Dimitri, Dalia, Trébeden-Nègre, Hélène, Jean, Laetitia, Bon-Durand, Véronique, Antonelli, David, Klatzmann, David, Boyer, Olivier
Format: Article
Language:English
Subjects:
Biological and medical sciences
Cell Proliferation
Cells, Cultured
Clone Cells
Development. Senescence. Regeneration. Transplantation
Fundamental and applied biological sciences. Psychology
Humans
Lymphocyte Activation
Medical sciences
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
Polymyositis - genetics
Polymyositis - immunology
Polymyositis - pathology
T-Lymphocytes - immunology
T-Lymphocytes - pathology
Time Factors
Vertebrates: nervous system and sense organs
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Summary:Polymyositis is a CD8+ T‐cell–mediated disease. T‐cell clonal expansions are observed at disease onset, but little is known about their persistence over time. Qualitative and quantitative spectratyping demonstrated that PM relapse features dramatically perturbed blood T‐cell repertoires but is not associated with the emergence of new T‐cell clones. It is striking that patients in remission also maintained all their T‐cell repertoire abnormalities. The clonally expanded T‐cells displayed a memory phenotype, expressed intracellular perforin, and dramatically responded to IL‐2, showing a potential to be reactivated upon appropriate conditions. These results indicate that persistent T‐cell clonal expansion is an important feature of polymyositis. Ann Neurol 2004
ISSN:0364-5134
1531-8249
DOI:10.1002/ana.20293