Effects of benfluorex–vitamin C supplementation on cutaneous capillaries of diabetic rats

The ultrastructural changes on capillaries of the dermis in diabetic and benfluorex–vitamin C treated diabetic rats have been investigated. Three groups of 21 Wistar albino rats were used in the examination: control, diabetes, and benfluorex–vitamin C treated diabetic rats. Diabetes was induced by i...

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Bibliographic Details
Published in:Cell biology international 2009-03, Vol.33 (3), p.442-446
Main Authors: Sari Kiliçaslan, Seda Mehtap, Ozer, Ciğdem
Format: Article
Language:English
Subjects:
Animals
Ascorbic Acid - pharmacology
Benfluorex
Capillaries - drug effects
Capillaries - ultrastructure
Capillary
Dermis - blood supply
Diabetes
Diabetes Mellitus, Experimental - pathology
Dietary Supplements
Disease Models, Animal
Endothelial Cells - pathology
Fenfluramine - analogs & derivatives
Fenfluramine - pharmacology
Hypolipidemic Agents - pharmacology
Rat
Rats
Rats, Wistar
Skin
Ultrastructure
Vitamin C
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Summary:The ultrastructural changes on capillaries of the dermis in diabetic and benfluorex–vitamin C treated diabetic rats have been investigated. Three groups of 21 Wistar albino rats were used in the examination: control, diabetes, and benfluorex–vitamin C treated diabetic rats. Diabetes was induced by injection of streptozotocin. The streptozotocin-induced group was treated for 21 days with vitamin C and benfluorex, of which antidiabetic and antihyperlipidemic effects were experimentally proved. Samples taken from the skin of rats' legs were examined under transmission electron microscopy. Swollen endothelial cells, narrowed capillary lumens, a thickened basement membrane, and fusion of mitochondrial cristae in the capillaries of diabetic rat dermis were seen. In the benfluorex–vitamin C treated group, contrary to the diabetic group, neither signs of degeneration in endothelial cells nor a significant difference with the control group with regard to capillary structure were observed. Amelioration in capillaries appears to be due to benfluorex and vitamin C treatment in diabetes.
ISSN:1065-6995
1095-8355
DOI:10.1016/j.cellbi.2009.01.009