A Novel Use for Drotrecogin Alfa (Activated): Successful Treatment of Septic Shock Associated with Coccidioidomycosis

We present 2 cases of septic shock associated with coccidioidomycosis that were successfully treated with drotrecogin alfa (activated) in combination with antifungal agents. The favorable outcomes, in light of the high mortality usually associated with this condition, suggest that drotrecogin alfa (...

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Bibliographic Details
Published in:Clinical infectious diseases 2004-12, Vol.39 (11), p.e122-e123
Main Authors: Crum, Nancy F., Groff, Harold L., Parrish, John S., Ring, William
Format: Article
Language:English
Subjects:
Aged
Anti-Infective Agents - therapeutic use
Coccidioidomycosis - complications
Coccidioidomycosis - drug therapy
Humans
Male
Middle Aged
Protein C - therapeutic use
Recombinant Proteins - therapeutic use
Remission Induction
Shock, Septic - drug therapy
Shock, Septic - etiology
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Summary:We present 2 cases of septic shock associated with coccidioidomycosis that were successfully treated with drotrecogin alfa (activated) in combination with antifungal agents. The favorable outcomes, in light of the high mortality usually associated with this condition, suggest that drotrecogin alfa (activated) may be a valuable adjunct for treating septic shock due to endemic mycoses.
ISSN:1058-4838
1537-6591
DOI:10.1086/425918