Determinants of Immune Reconstitution Inflammatory Syndrome in HIV Type 1-Infected Patients with Tuberculosis after Initiation of Antiretroviral Therapy

Immune reconstitution inflammatory syndrome (IRIS) occurred in 16 of 37 antiretroviral-naive patients who were treated subsequently for tuberculosis and human immunodeficiency virus (HIV) type 1 infection. IRIS was related to increases in the CD4 cell percentage and in the ratio of CD4 cells to CD8...

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Bibliographic Details
Published in:Clinical infectious diseases 2004-12, Vol.39 (11), p.1709-1712
Main Authors: Breton, Guillaume, Duval, Xavier, Estellat, Candice, Poaletti, Xavier, Bonnet, Daniel, Mvondo, David Mvondo, Longuet, Pascale, Leport, Catherine, Vildé, Jean-Louis
Format: Article
Language:English
Subjects:
Adult
AIDS
Anti-Retroviral Agents - therapeutic use
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiretrovirals
Antiviral agents
Bacterial diseases
Biological and medical sciences
Cellular immunity
Female
Highly active antiretroviral therapy
HIV 1
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - immunology
HIV/AIDS
Human bacterial diseases
Human immunodeficiency virus 1
Human viral diseases
Humans
Infectious diseases
Inflammation - etiology
Male
Medical sciences
Middle Aged
Mycobacterium tuberculosis
Percentages
Pharmacology. Drug treatments
Retrospective Studies
RNA
Syndrome
T lymphocytes
Tuberculosis
Tuberculosis - complications
Tuberculosis - immunology
Tuberculosis and atypical mycobacterial infections
Viral diseases
Viral diseases of the lymphoid tissue and the blood. Aids
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Summary:Immune reconstitution inflammatory syndrome (IRIS) occurred in 16 of 37 antiretroviral-naive patients who were treated subsequently for tuberculosis and human immunodeficiency virus (HIV) type 1 infection. IRIS was related to increases in the CD4 cell percentage and in the ratio of CD4 cells to CD8 cells after 1 month of antiretroviral therapy and to dissemination of tuberculosis. These results have implications for the diagnosis of IRIS and the understanding of its pathogenesis.
ISSN:1058-4838
1537-6591
DOI:10.1086/425742