Adipose tissue in Walker 256 tumour-induced cachexia: possible association between decreased leptin concentration and mononuclear cell infiltration

The adipose tissue (AT) is severely affected by cachexia, a paraneoplastic syndrome, which increases the morbidity and mortality of cancer. There is, however, a heterogeneous response to the condition, according to the AT depot. As plasma leptin concentration has been often reported to vary in cache...

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Bibliographic Details
Published in:Cell and tissue research 2004-12, Vol.318 (3), p.503-514
Main Authors: Machado, Adriana P, Costa Rosa, Luis F P B, Seelaender, Marilia C L
Format: Article
Language:English
Subjects:
Adipose Tissue - metabolism
Adipose Tissue - pathology
Animals
Body fat
Cachexia - etiology
Cachexia - metabolism
Cachexia - pathology
Carcinoma 256, Walker - immunology
Carcinoma 256, Walker - metabolism
Carcinoma 256, Walker - pathology
Dinoprostone - metabolism
Histocompatibility Antigens - metabolism
Leptin - metabolism
Macrophages - immunology
Macrophages - metabolism
Macrophages - pathology
Macrophages, Peritoneal - metabolism
Macrophages, Peritoneal - ultrastructure
Male
Rats
Rats, Wistar
Tumor Cells, Cultured - transplantation
Tumor Necrosis Factor-alpha - metabolism
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Summary:The adipose tissue (AT) is severely affected by cachexia, a paraneoplastic syndrome, which increases the morbidity and mortality of cancer. There is, however, a heterogeneous response to the condition, according to the AT depot. As plasma leptin concentration has been often reported to vary in cachexia, we have measured (species specific radioimmunoassay) the local concentration of leptin in three AT depots: retroperitoneal (RPAT), epididymal (EAT) and mesenteric (MES) of Walker 256 tumour-bearing rats. A reduced concentration of leptin ( P
ISSN:0302-766X
1432-0878
DOI:10.1007/s00441-004-0987-2