Leiomyomatosis peritonealis disseminata with malignant change in a post-menopausal woman

Leiomyomatosis peritonealis disseminata (LPD) is a rare condition characterized by multiple subperitoneal nodules of benign smooth muscle. The lesion usually occurs in women of childbearing age. A 55-year-old woman with a history of panhysterectomy 8 years ago presented with an abdominal lump. Ultra...

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Bibliographic Details
Published in:Gynecologic oncology 2004-12, Vol.95 (3), p.742-745
Main Authors: Sharma, Prashant, Chaturvedi, K. Uma, Gupta, Ruchika, Nigam, Sonu
Format: Article
Language:English
Subjects:
Cell Transformation, Neoplastic - pathology
Female
Humans
Leiomyomatosis - pathology
Leiomyomatosis - surgery
Leiomyomatosis peritonealis disseminata
Leiomyosarcoma
Middle Aged
Omentum - pathology
Peritoneal Neoplasms - pathology
Peritoneal Neoplasms - surgery
Post-menopausal
Postmenopause
Sarcomatous transformation
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Summary:Leiomyomatosis peritonealis disseminata (LPD) is a rare condition characterized by multiple subperitoneal nodules of benign smooth muscle. The lesion usually occurs in women of childbearing age. A 55-year-old woman with a history of panhysterectomy 8 years ago presented with an abdominal lump. Ultrasonographic and peroperative finding of multiple omental nodules led to a clinical impression of disseminated malignancy. Only the largest nodule was excised, histopathology of which revealed a cellular leiomyoma. Seven months later, she developed an omental leiomyosarcoma. An omentectomy was done and the multiple smaller nodules were all confirmed to be composed of benign leiomyocytes. Malignant transformation in LPD in post-menopausal patients is an exceptional event that has been documented only twice previously in English literature.
ISSN:0090-8258
1095-6859
DOI:10.1016/j.ygyno.2004.09.007