Genetic alterations in chronic lymphocytic leukaemia

Chronic lymphocytic leukaemia (CLL), the commonest form of leukaemia in adults in Western countries, is a genetically heterogeneous disease. The most frequent genetic alterations are deletions in 13q14, 17p13 (TP53) and 11q22–q23 (ATM) , and trisomy of chromosome 12. Furthermore, additional alterati...

Full description

Saved in:
Bibliographic Details
Published in:Clinical & translational oncology 2009-04, Vol.11 (4), p.194-198
Main Authors: Coll-Mulet, Llorenç, Gil, Joan
Format: Article
Language:English
Subjects:
Chromosome Aberrations
Educational Series
Genetic Variation
Humans
In Situ Hybridization, Fluorescence
Leukemia, Lymphocytic, Chronic, B-Cell - genetics
Leukemia, Lymphocytic, Chronic, B-Cell - pathology
Medicine
Medicine & Public Health
Nucleic Acid Hybridization
Oncology
Polymerase Chain Reaction
Tumor Suppressor Protein p53 - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Chronic lymphocytic leukaemia (CLL), the commonest form of leukaemia in adults in Western countries, is a genetically heterogeneous disease. The most frequent genetic alterations are deletions in 13q14, 17p13 (TP53) and 11q22–q23 (ATM) , and trisomy of chromosome 12. Furthermore, additional alterations have been described. The most relevant techniques used for detection of genetic alterations in CLL include comparative genomic hybridisation (CGH) and fluorescence in situ hybridisation (FISH). Recently, PCR-based techniques, such as multiplex ligation-dependent probe amplification (MLPA), have been used to detect genetic alterations in CLL. This review summarises the genetic alterations described in CLL and the techniques used for their detection.
ISSN:1699-048X
1699-3055
DOI:10.1007/s12094-009-0340-z