(+)-Methamphetamine-induced spontaneous behavior in rats depends on route of (+)METH administration

These studies examined the role of (+)-methamphetamine ((+)METH) administration route on spontaneous behavioral activity vs. time relationships, and pharmacokinetic mechanisms for differences in effects. Male Sprague–Dawley rats ( n=6 per administration route) received saline and three doses (0.3, 1...

Full description

Saved in:
Bibliographic Details
Published in:Pharmacology, biochemistry and behavior biochemistry and behavior, 2004-12, Vol.79 (4), p.751-760
Main Authors: Gentry, W. Brooks, Ghafoor, Abid U., Wessinger, William D., Laurenzana, Elizabeth M., Hendrickson, Howard P., Owens, S. Michael
Format: Article
Language:English
Subjects:
Administration route
Amphetamine
Animals
Behavioral psychophysiology
Biological and medical sciences
Dose-Response Relationship, Drug
Dose–response relationships
Fundamental and applied biological sciences. Psychology
Locomotor activity
Male
Methamphetamine
Methamphetamine - administration & dosage
Methamphetamine - blood
Miscellaneous
Motor Activity - drug effects
Motor Activity - physiology
Pharmacokinetics
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rat
Rats
Rats, Sprague-Dawley
Stereotyped Behavior - drug effects
Stereotyped Behavior - physiology
Stereotypy
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:These studies examined the role of (+)-methamphetamine ((+)METH) administration route on spontaneous behavioral activity vs. time relationships, and pharmacokinetic mechanisms for differences in effects. Male Sprague–Dawley rats ( n=6 per administration route) received saline and three doses (0.3, 1.0 and 3.0 mg/kg) of (+)METH in a mixed-sequence design by intravenous (iv), subcutaneous (sc) or intraperitoneal (ip) administration. Locomotion and stereotypy were quantified by video-tracking analysis. The effects of (+)METH on spontaneous behavior were dose- and route-dependent. In particular, total locomotor activity was greatest following 3.0 mg/kg intraperitoneally ( P
ISSN:0091-3057
1873-5177
DOI:10.1016/j.pbb.2004.10.006