Artichoke juice improves endothelial function in hyperlipemia

Artichoke extracts have been shown to produce various pharmacological effects, such as the inhibition of cholesterol biosynthesis and of LDL oxidation. Endothelial dysfunction represents the first stage of atherosclerotic disease; it is usually evaluated in humans by a noninvasive ultrasound method...

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Bibliographic Details
Published in:Life sciences (1973) 2004-12, Vol.76 (7), p.775-782
Main Authors: Lupattelli, Graziana, Marchesi, Simona, Lombardini, Rita, Roscini, Anna Rita, Trinca, Franco, Gemelli, Fabio, Vaudo, Gaetano, Mannarino, Elmo
Format: Article
Language:English
Subjects:
Adult
Artichoke
Blood Flow Velocity - drug effects
Brachial Artery - drug effects
Brachial Artery - physiopathology
Cholesterol, HDL - blood
Cholesterol, LDL - blood
Cynara scolymus - chemistry
Dietary Supplements
E-Selectin - blood
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiopathology
Female
Flow mediated vasodilation
Humans
Hyperlipemia
Hyperlipidemias - blood
Hyperlipidemias - drug therapy
Hypolipidemic Agents - therapeutic use
Intercellular Adhesion Molecule-1 - blood
Lipoproteins, LDL - blood
Male
Middle Aged
Plant Extracts - therapeutic use
Triglycerides - blood
Vascular Cell Adhesion Molecule-1 - blood
Vasodilation - drug effects
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Summary:Artichoke extracts have been shown to produce various pharmacological effects, such as the inhibition of cholesterol biosynthesis and of LDL oxidation. Endothelial dysfunction represents the first stage of atherosclerotic disease; it is usually evaluated in humans by a noninvasive ultrasound method as brachial flow-mediated vasodilation (FMV) and by the determination of several humoral markers such as vascular cell adhesion molecule-1 (VCAM-1), intercellular adhesion molecule-1 (ICAM-1), and E-selectin. Aim of the study was to investigate the effects of dietary supplementation with artichoke juice on brachial FMV of hyperlipemics. We studied 18 moderately hyperlipemic patients (LDL cholesterol > 130 150
ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2004.07.018