Prevalence of hepatitis B virus genotypes and the occurrence of precore mutation A-1896 and to correlate them with the clinical presentation of chronic hepatitis, in a population group of the Eastern Amazon region

Hepatitis B virus (HBV) infection presents itself with a variety of clinical manifestations. The present work aims to describe the prevalence of HBV genotypes and the occurrence of precore mutation A-1896 in a population group of the Eastern Amazon region of Brazil and to correlate them with the cli...

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Published in:Revista da Sociedade Brasileira de Medicina Tropical 2004, Vol.37 Suppl 2, p.33-39
Main Authors: Conde, Simone Regina Souza da Silva, Móia, Lizomar de Jesus Pereira, Barbosa, Maria Silvia Brito, Amaral, Ivanete do Socorro Abarcado, Miranda, Esther Castello Branco de Mello, Soares, Manoel do Carmo Pereira, Brito, Elizabete Maria de Figueiredo, Souza, Olglaíze do Socorro Costa, de Araújo, Marialva Tereza, Demachki, Sâmia, Rebello, João Renato Pinho, Mesquita, Michele Gomes Soares, Denis, Alberto Bertollini, Ishak, Ricardo
Format: Article
Language:Portuguese
Subjects:
Adolescent
Adult
Aged
Aged, 80 and over
Base Sequence
Brazil
Child
Child, Preschool
DNA, Viral - analysis
Female
Genotype
Hepatitis B Core Antigens - blood
Hepatitis B Core Antigens - genetics
Hepatitis B Surface Antigens - blood
Hepatitis B virus - genetics
Hepatitis B virus - immunology
Hepatitis B, Chronic - virology
Humans
Infant
Male
Middle Aged
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Prevalence
Viral Load
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Summary:Hepatitis B virus (HBV) infection presents itself with a variety of clinical manifestations. The present work aims to describe the prevalence of HBV genotypes and the occurrence of precore mutation A-1896 in a population group of the Eastern Amazon region of Brazil and to correlate them with the clinical presentation of chronic HBV infection. 51 HBsAg carriers (HBV-DNA positive) were selected and divided into three groups: A (14 asymptomatic subjects), B (20 HBeAg positive symptomatic patients) and C (17 HBeAg negative symptomatic patients). Using an automa ed DNA sequencer ABI model 377 by sequencing for determined of genotypes and precore mutation. The results showed that the genotype A was the most commonly found (81.1%, 89.5% and 93.7% in groups A, B and C, respectively) and precore mutation A-1896 was described in 11.5% (3/26) of group A subjects. Genotype A of HBV was the most prevalent (89.1%) and low occurrence of precore mutation A-1896, both not associate with the worst outcome of the chronic infection of HBV.
ISSN:0037-8682