Spatial localization and time‐dependant changes of electrographic high frequency oscillations in human temporal lobe epilepsy

Summary Purpose:  High frequency oscillations (HFOs) >200 Hz are believed to be associated with epileptic processes. The spatial distribution of HFOs and their evolution over time leading up to seizure onset is unknown. Also, recording HFOs through conventional intracranial electrodes is not well...

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Bibliographic Details
Published in:Epilepsia (Copenhagen) 2009-04, Vol.50 (4), p.605-616
Main Authors: Khosravani, Houman, Mehrotra, Nikhil, Rigby, Michael, Hader, Walter J., Pinnegar, C. Robert, Pillay, Neelan, Wiebe, Samuel, Federico, Paolo
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Anticonvulsants. Antiepileptics. Antiparkinson agents
Biological and medical sciences
Brain Mapping
Electroencephalography
Epilepsy, Temporal Lobe - pathology
Epilepsy, Temporal Lobe - physiopathology
Fast ripples
Female
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
High frequency
Humans
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Neuropharmacology
Pharmacology. Drug treatments
Retrospective Studies
Ripples
Seizure localization
Temporal lobe epilepsy
Time Factors
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Summary:Summary Purpose:  High frequency oscillations (HFOs) >200 Hz are believed to be associated with epileptic processes. The spatial distribution of HFOs and their evolution over time leading up to seizure onset is unknown. Also, recording HFOs through conventional intracranial electrodes is not well established. We therefore wished to determine whether HFOs could be recorded using commercially available depth macroelectrodes. We also examined the spatial distribution and temporal progression of HFOs during the transition to seizure activity. Methods:  Intracranial electroencephalography (EEG) recordings of 19 seizures were obtained from seven patients with temporal lobe epilepsy using commercial depth or subdural electrodes. EEG recordings were analyzed for frequency content in five spectral bands spanning DC‐500 Hz. We examined the spatial distribution of the different spectral bands 5 s before and 5 s after seizure onset. Temporal changes in the spectral bands were studied in the 30‐s period leading up to seizure onset. Results:  Three main observations were made. First, HFOs (100–500 Hz) can be recorded using commercial depth and subdural grid electrodes. Second, HFOs, but not
ISSN:0013-9580
1528-1167
DOI:10.1111/j.1528-1167.2008.01761.x