Increased frequencies of serum antibodies to neurofilament light in patients with primary chronic progressive multiple sclerosis

We investigated whether serum and cerebrospinal fluid (CSF) antibodies to the light subunit of the NF protein (NF-L), a main component of the axonal cytoskeleton, may serve as biological markers for axonal pathology and/or disease progression in multiple sclerosis (MS). IgG to NF-L was measured in s...

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Bibliographic Details
Published in:Multiple sclerosis 2004-12, Vol.10 (6), p.601-606
Main Authors: Ehling, R, Lutterotti, A, Wanschitz, J, Khalil, M, Gneiss, C, Deisenhammer, F, Reindl, M, Berger, T
Format: Article
Language:English
Subjects:
Adult
Aged
Animals
Antibody Specificity
Autoantibodies - blood
Autoantibodies - cerebrospinal fluid
Axons - pathology
Biological and medical sciences
Biomarkers
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Enzyme-Linked Immunosorbent Assay
Female
Humans
Immunomodulators
Medical sciences
Middle Aged
Multiple Sclerosis, Chronic Progressive - immunology
Multiple Sclerosis, Chronic Progressive - pathology
Neurofilament Proteins - immunology
Neurology
Pharmacology. Drug treatments
Recombinant Proteins - immunology
Swine
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Summary:We investigated whether serum and cerebrospinal fluid (CSF) antibodies to the light subunit of the NF protein (NF-L), a main component of the axonal cytoskeleton, may serve as biological markers for axonal pathology and/or disease progression in multiple sclerosis (MS). IgG to NF-L was measured in sera and CSF of MS patients, patients with inflammatory demyelinating diseases of the PNS, with acute inflammatory neurological diseases (including bacterial and viral meningitis), with neurodegenerative diseases, with acute noninflammatory neurological diseases (including stroke, headache and backache) and healthy controls by enzyme-linked immunosorbent assay. We found that serum anti-NF-L IgG antibodies were significantly elevated in MS patients with primary progressive disease course and we provide evidence for an intrathecal production of these antibodies. Our findings support the use of serum antibodies to NF-L as a marker for axonal destruction.
ISSN:1352-4585
1477-0970
DOI:10.1191/1352458504ms1100oa