Targeting RNAs with Tobramycin Analogues

A library of 4,6‐linked analogues of the drug tobramycin with various mono‐ or diaminosugars attached to the 6‐position of the two‐ring core has been prepared (see scheme; Bn=benzyl, Tol=p‐tolyl). The compounds were screened against different disease‐related RNAs, and several of the synthetic analog...

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Bibliographic Details
Published in:Angewandte Chemie International Edition 2004-12, Vol.43 (47), p.6496-6500
Main Authors: Liang, Fu-Sen, Wang, Sheng-Kai, Nakatani, Takuji, Wong, Chi-Huey
Format: Article
Language:English
Subjects:
carbohydrates
drug design
glycosylation
Humans
Molecular Structure
RNA - chemistry
RNA recognition
Sensitivity and Specificity
Substrate Specificity
Sulfhydryl Compounds - chemistry
surface plasmon resonance
Tobramycin - analogs & derivatives
Tobramycin - chemical synthesis
Tobramycin - chemistry
Tobramycin - pharmacology
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Summary:A library of 4,6‐linked analogues of the drug tobramycin with various mono‐ or diaminosugars attached to the 6‐position of the two‐ring core has been prepared (see scheme; Bn=benzyl, Tol=p‐tolyl). The compounds were screened against different disease‐related RNAs, and several of the synthetic analogues showed a high affinity and selectivity toward certain RNA sequences.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.200460558