Dendrimers as synthetic gene vectors: Cell membrane attachment

We present molecular-level simulations of dendrimer/DNA complexes in the presence of a model cell membrane. We determine the required conditions for the complex to arrive intact at the membrane, and the lifetime of the complex as it resides attached to the membrane. Our simulations directly pertain...

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Bibliographic Details
Published in:The Journal of chemical physics 2009-04, Vol.130 (15), p.155101-155101-5
Main Authors: Voulgarakis, N. K., Rasmussen, K. Ø., Welch, P. M.
Format: Article
Language:English
Subjects:
Cell Membrane - chemistry
Computer Simulation
Dendrimers - chemistry
DNA - chemistry
Genetic Vectors - chemical synthesis
Genetic Vectors - chemistry
Models, Molecular
Probability
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Summary:We present molecular-level simulations of dendrimer/DNA complexes in the presence of a model cell membrane. We determine the required conditions for the complex to arrive intact at the membrane, and the lifetime of the complex as it resides attached to the membrane. Our simulations directly pertain to critical issues arising in emerging gene delivery therapeutic applications, where a molecular carrier is required to deliver DNA segments to the interior of living cells.
ISSN:0021-9606
1089-7690
DOI:10.1063/1.3109902