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Potential relevance of cerebrospinal fluid and serum levels and intrathecal synthesis of active matrix metalloproteinase-2 (MMP-2) as markers of disease remission in patients with multiple sclerosis
Background Little is known about the involvement of matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor TIMP-2 in multiple sclerosis (MS). Objective To elucidate the actual implication of MMP-2 and TIMP-2 in MS. Methods Cerebrospinal fluid (CSF) and serum levels of active MMP-2 and TIMP-2 we...
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Published in: | Multiple sclerosis 2009-05, Vol.15 (5), p.547-554 |
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Main Authors: | , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Background
Little is known about the involvement of matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor TIMP-2 in multiple sclerosis (MS).
Objective
To elucidate the actual implication of MMP-2 and TIMP-2 in MS.
Methods
Cerebrospinal fluid (CSF) and serum levels of active MMP-2 and TIMP-2 were measured by activity assay system and ELISA, respectively, in 67 patients with relapsing–remitting MS (RRMS), categorized according clinical and magnetic resonance imaging (MRI), and in 129 controls.
Results
Cerebrospinal fluid and serum active MMP-2/TIMP-2 ratio mean values and an intrathecal active MMP-2 production were more increased in RRMS than in non-inflammatory conditions (P |
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ISSN: | 1352-4585 1477-0970 |
DOI: | 10.1177/1352458509102372 |