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Potential relevance of cerebrospinal fluid and serum levels and intrathecal synthesis of active matrix metalloproteinase-2 (MMP-2) as markers of disease remission in patients with multiple sclerosis

Background Little is known about the involvement of matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor TIMP-2 in multiple sclerosis (MS). Objective To elucidate the actual implication of MMP-2 and TIMP-2 in MS. Methods Cerebrospinal fluid (CSF) and serum levels of active MMP-2 and TIMP-2 we...

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Bibliographic Details
Published in:Multiple sclerosis 2009-05, Vol.15 (5), p.547-554
Main Authors: Fainardi, E, Castellazzi, M, Tamborino, C, Trentini, A, Manfrinato, MC, Baldi, E, Tola, MR, Dallocchio, F, Granieri, E, Bellini, T
Format: Article
Language:English
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Summary:Background Little is known about the involvement of matrix metalloproteinase-2 (MMP-2) and its tissue inhibitor TIMP-2 in multiple sclerosis (MS). Objective To elucidate the actual implication of MMP-2 and TIMP-2 in MS. Methods Cerebrospinal fluid (CSF) and serum levels of active MMP-2 and TIMP-2 were measured by activity assay system and ELISA, respectively, in 67 patients with relapsing–remitting MS (RRMS), categorized according clinical and magnetic resonance imaging (MRI), and in 129 controls. Results Cerebrospinal fluid and serum active MMP-2/TIMP-2 ratio mean values and an intrathecal active MMP-2 production were more increased in RRMS than in non-inflammatory conditions (P 
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458509102372