Weight Loss Reduces Circulating Asymmetrical Dimethylarginine Concentrations in Morbidly Obese Women

The endogenous nitric oxide-synthase inhibitor asymmetrical dimethyl-l-arginine (ADMA) is elevated in patients with increased risk for arteriosclerosis. Obesity is a risk factor for cardiovascular disease. We measured plasma ADMA concentrations in morbidly obese women before and after weight loss fo...

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Published in:The journal of clinical endocrinology and metabolism 2004-12, Vol.89 (12), p.6277-6281
Main Authors: Krzyzanowska, Katarzyna, Mittermayer, Friedrich, Kopp, Hans-Peter, Wolzt, Michael, Schernthaner, Guntram
Format: Article
Language:English
Subjects:
Adult
Arginine - analogs & derivatives
Arginine - blood
Biological and medical sciences
Body Mass Index
Case-Control Studies
Chromatography, High Pressure Liquid
Endocrinopathies
Female
Fundamental and applied biological sciences. Psychology
Gastroplasty
Humans
Medical sciences
Middle Aged
Obesity, Morbid - blood
Obesity, Morbid - pathology
Obesity, Morbid - surgery
Osmolar Concentration
Vertebrates: endocrinology
Weight Loss
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Summary:The endogenous nitric oxide-synthase inhibitor asymmetrical dimethyl-l-arginine (ADMA) is elevated in patients with increased risk for arteriosclerosis. Obesity is a risk factor for cardiovascular disease. We measured plasma ADMA concentrations in morbidly obese women before and after weight loss following gastroplastic surgery. ADMA and symmetrical dimethyl-l-arginine concentrations were analyzed by HPLC from 34 female patients (age 41 ± 7 yr) with a body mass index (BMI) of 49 ± 1 kg/m2 before and 14 months after vertical ring gastroplasty. Age-matched healthy women (BMI < 25 kg/m2; n = 24) were studied as controls. After gastroplastic surgery, BMI decreased to 34 ± 1 kg/m2 in obese women (P < 0.00001), and ADMA concentrations were reduced from 1.06 ± 0.06 μmol/liter at baseline to 0.81 ± 0.04 μmol/liter after weight loss (P < 0.00001). Symmetrical dimethyl-l-arginine plasma levels were not affected. ADMA correlated with high-sensitivity C-reactive protein at baseline (r = 0.42; P < 0.05) and after weight loss (r = 0.56; P < 0.005). No association with blood pressure or plasma lipids could be observed. ADMA concentrations were lower in controls (0.68 ± 0.04 μmol/liter; P < 0.05) compared with obese patients before or after weight reduction. The decrease of highly elevated ADMA concentrations in morbidly obese patients is paralleled by improvement of parameters associated with the metabolic syndrome after weight loss.
ISSN:0021-972X
1945-7197
DOI:10.1210/jc.2004-0672