Self-assembly and evolution of homomeric protein complexes

We introduce a simple "patchy particle" model to study the thermodynamics and dynamics of self-assembly of homomeric protein complexes. Our calculations allow us to rationalize recent results for dihedral complexes. Namely, why evolution of such complexes naturally takes the system into a...

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Bibliographic Details
Published in:Physical review letters 2009-03, Vol.102 (11), p.118106-118106, Article 118106
Main Authors: Villar, Gabriel, Wilber, Alex W, Williamson, Alex J, Thiara, Parvinder, Doye, Jonathan P K, Louis, Ard A, Jochum, Mara N, Lewis, Anna C F, Levy, Emmanuel D
Format: Article
Language:English
Subjects:
Algorithms
Models, Chemical
Monte Carlo Method
Proteins - chemistry
Proteins - metabolism
Thermodynamics
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Summary:We introduce a simple "patchy particle" model to study the thermodynamics and dynamics of self-assembly of homomeric protein complexes. Our calculations allow us to rationalize recent results for dihedral complexes. Namely, why evolution of such complexes naturally takes the system into a region of interaction space where (i) the evolutionarily newer interactions are weaker, (ii) subcomplexes involving the stronger interactions are observed to be thermodynamically stable on destabilization of the protein-protein interactions, and (iii) the self-assembly dynamics are hierarchical with these same subcomplexes acting as kinetic intermediates.
ISSN:0031-9007
1079-7114
DOI:10.1103/physrevlett.102.118106